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首页> 外文期刊>Vaccine >Human papillomavirus (HPV), HPV-associated oropharyngeal cancer, and HPV vaccine in the United States-Do we need a broader vaccine policy?
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Human papillomavirus (HPV), HPV-associated oropharyngeal cancer, and HPV vaccine in the United States-Do we need a broader vaccine policy?

机译：在美国，人类乳头瘤病毒（HPV），与HPV相关的口咽癌和HPV疫苗-我们需要更广泛的疫苗政策吗？

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Background: Human papillomavirus (HPV) is a sexually transmitted infection (STI) of global importance; it is the most prevalent STI in the United States, with strains causally linked to oropharyngeal and other cancers. Efforts to prevent HPV have been made to varying degrees by policies implemented by different state governments; however, HPV and associated oropharyngeal cancer continue to show increasing incidence rates in the US. Design: A narrative review based on search on SciVerse, PubMed/Medline, Google Scholar, and EMBASE databases, as well as literature/documents from the World Health Organization, Centers for Disease Control and Prevention, American Cancer Society, National Conference of State legislatures, and the U.S. Department of Health and Human Services relevant to HPV and HPV vaccine policy in the US. Results: Vaccination has proved to be a successful policy in the US, and an extant recommendation aimed at preventing HPV and associated cervical and other anogenital cancers is the routine use of HPV vaccines for males and females. However, HPV vaccines are presently not recommended for preventing oropharyngeal cancer, although they have been shown to be highly effective against the HPV strains that are most commonly found in the oropharynx. And while there is a history of successful vaccine mandate in the US with resulting decrease in occurrence of infectious diseases, implementing HPV vaccine mandate has proved to be very unpopular. Conclusions: With emerging evidence of the efficacy of the use of the HPV vaccine in preventing oral-HPV, more focus should be put on extending HPV vaccine to present oral HPV infection and oropharyngeal cancer. Also, implementing a broader HPV vaccine policy that include mandating HPV vaccines as a school-entry requirement for both sexes may increase vaccine use in the US for the greater good of the public
机译：背景：人乳头瘤病毒（HPV）是一种具有全球重要性的性传播感染（STI）。它是美国最流行的性传播感染，其菌株与口咽癌和其他癌症有因果关系。不同州政府实施的政策已在不同程度上做出了预防HPV的努力。然而，在美国，HPV和相关的口咽癌的发病率继续上升。设计：根据SciVerse，PubMed / Medline，Google Scholar和EMBASE数据库以及世界卫生组织，疾病控制和预防中心，美国癌症协会，美国国家立法机关会议的文献/文档进行搜索，对叙述进行回顾以及与美国HPV和HPV疫苗政策有关的美国卫生与公共服务部。结果：在美国，疫苗接种已被证明是一项成功的政策，针对预防HPV以及相关的子宫颈癌和其他肛门生殖器癌的现有建议是，男性和女性常规使用HPV疫苗。但是，尽管已证明HPV疫苗对口咽中最常见的HPV株具有很高的效果，但目前不建议它们用于预防口咽癌。尽管在美国已有成功实施疫苗授权并导致传染病发生率下降的历史，但事实证明，实施HPV疫苗授权非常不受欢迎。结论：随着越来越多的证据表明使用HPV疫苗预防口腔HPV的功效，应更加关注扩大HPV疫苗的应用范围，以呈现口腔HPV感染和口咽癌。此外，实施更广泛的HPV疫苗政策，包括将HPV疫苗作为男女两性的入学要求，可能会在美国增加疫苗的使用，从而造福于大众

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