...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >Reduced incidence of invasive pneumococcal disease after introduction of the 13-valent conjugate vaccine in Navarre, Spain, 2001-2013
【24h】

Reduced incidence of invasive pneumococcal disease after introduction of the 13-valent conjugate vaccine in Navarre, Spain, 2001-2013

机译：2001-2013年在西班牙纳瓦拉引入13价结合疫苗后，侵袭性肺炎球菌疾病的发病率降低

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pneumococcal conjugate vaccines (PCVs) were licensed for use in children and became available for private purchase in Spain in 2001 (PCV7), 2009 (PCV10) and 2010 (PCV13). This study evaluates changes in the incidence of invasive pneumococcal disease (IPD) and the pattern of serotypes isolated in Navarre, Spain, between the period of use of PCV7 (2004-2009) and that of PCV13 (2010-2013). The percentage of children <2 years who received at least one dose of PCV in these periods ranged from 25 to 61% and 61 to 78%, respectively. Between the periods 2004-2009 and 2010-2013 IPD incidence declined by 37%, from 14.9 to 9.4 cases/100,000 inhabitants (p <0.001). In children <5 years it fell by 69% (p <0.001), in persons aged 5-64 years, by 34% (p <0.001), and in those >= 65, by 23% (p = 0.024). The incidence of cases due to PCV13 serotypes declined by 81% (p <0.001) in children <5 years and by 52% (p <0.001) in the whole population. No significant changes were seen in the distribution of clinical presentations or in disease severity. The incidence of IPD has declined and the pattern of serotypes causing IPD has changed notably in children and moderately in adults following the replacement of PCV7 by PCV13
机译：肺炎球菌结合疫苗（PCV）已获准用于儿童，并于2001年（PCV7），2009（PCV10）和2010（PCV13）在西班牙私人购买。这项研究评估了在PCV7（2004-2009）和PCV13（2010-2013）使用期间，西班牙纳瓦拉（Navarre）的侵袭性肺炎球菌疾病（IPD）发病率变化和血清型分布。在这些时期内接受至少一剂PCV的<2岁儿童的百分比分别为25％至61％和61％至78％。在2004-2009年至2010-2013年期间，IPD发病率下降了37％，从每10万名居民中的14.9例下降到9.4例（p <0.001）。 <5岁的儿童下降了69％（p <0.001），5-64岁的儿童下降了34％（p <0.001），而> = 65岁的人们下降了23％（p = 0.024）。 <5岁儿童中PCV13血清型引起的病例发生率下降了81％（p <0.001），而在整个人群中下降了52％（p <0.001）。在临床表现的分布或疾病严重性方面未见明显变化。在PCV13取代PCV7之后，IPD的发病率下降了，引起IPD的血清型发生了显着变化，儿童和成人均发生了中度变化

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号