Vaccination of cattle with a recombinant bivalent toxoid against botulism serotypes C and D.

Cunha C. E. P.; Moreira G. M. S. G.; Salvarani F. M.; Neves M. S.; Lobato F. C. F.; Dellagostin O. A.; Conceicao F. R.

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Vaccination of cattle with a recombinant bivalent toxoid against botulism serotypes C and D.

机译：用重组的二价类毒素对肉毒杆菌血清型C和D接种牛。

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Cattle botulism is a fatal intoxication caused by botulinum neurotoxins (BoNTs) produced by Clostridium botulinum serotypes C and D resulting in economic losses. Vaccination is the most effective way to control botulism. However, the commercially available vaccines are difficult and hazardous to produce. Neutralizing antibodies against the C-terminal fragment of the BoNT heavy chain (H_C) are known to protect against lethal doses of BoNTs. We report the vaccination of cattle with a previously tested recombinant chimera consisting of Escherichia coli heat-labile enterotoxin B subunit and the H_C of BoNTs C and D. Vaccinated animals produced neutralizing antibodies against serotypes C and D averaging 5+or-0 and 6.14+or-1.06 IU/mL, respectively. For BoNT D, the titers were greater than those measured for the commercial vaccine, which induced titers of 5+or-0 and 2.85+or-1.35 against the respective serotypes, suggesting that this chimera is effective against cattle botulism.

机译：牛肉毒杆菌中毒是由肉毒梭菌C型和D型肉毒杆菌产生的肉毒杆菌神经毒素（BoNT）引起的致命性中毒，造成经济损失。接种疫苗是控制肉毒中毒的最有效方法。但是，市售疫苗难以生产且危险。已知针对BoNT重链C末端片段（H _{C ）的中和抗体可以防止致命剂量的BoNT。我们报告了牛的疫苗接种情况，该疫苗先前已测试过，由大肠杆菌耐热不稳定肠毒素B亚基和BoNT C和D的H _{C 组成的重组嵌合体。接种过的动物产生了针对血清C型和D型平均抗体5 + or-0和6.14 + or-1.06 IU / mL。对于BoNT D，滴度大于商业疫苗的滴度，商业疫苗可诱导针对相应血清型的5 + or-0和2.85 + or-1.35滴度，表明该嵌合体可有效抵抗牛肉毒中毒。}}

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《Vaccine》 |2014年第2期|共3页
作者
Cunha C. E. P.; Moreira G. M. S. G.; Salvarani F. M.; Neves M. S.; Lobato F. C. F.; Dellagostin O. A.; Conceicao F. R.;
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正文语种 eng
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Recombinant vaccine; Fused antigens; Clostridium botulinum; Botulinum neurotoxins; LTB;

机译：重组疫苗;融合抗原;肉毒梭菌;肉毒杆菌神经毒素;LTB;

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专利

1. Vaccination of cattle with a recombinant bivalent toxoid against botulism serotypes C and D. [J] . Cunha C. E. P., Moreira G. M. S. G., Salvarani F. M., Vaccine . 2014,第2期

机译：用重组的二价类毒素对肉毒杆菌血清型C和D接种牛。
2. Vaccination of cattle with a recombinant bivalent toxoid against botulism serotypes C and D. [J] . Cunha C. E. P., Moreira G. M. S. G., Salvarani F. M., Vaccine . 2014,第2期

机译：用重组的二价类毒素对肉毒杆菌血清型C和D接种牛。
3. Decreased STEC shedding by cattle following passive and active vaccination based on recombinant Escherichia coli Shiga toxoids [J] . Nadine Schmidt, Stefanie A. Barth, Jana Frahm, Veterinary research . 2018,第1期

机译：基于重组大肠杆菌志贺类毒素的被动和主动接种后，牛的STEC脱落减少
4. In Vivo Evaluation of Diphtheria Toxoid Encapsulated in PLGA Microspheres for Single-shot Vaccination [C] . Mikyeong Yoon, Jaehwi Lee, Young Wook Choi Annual meeting exposition of the Controlled Release Society . 2005

机译：单次接种PLGA微球中封装的白喉类毒素的体内评价
5. Immunology of BCG vaccination in mice: Implications for tuberculosis vaccination and for the use of BCG as a recombinant vaccine vector. [D] . Power, Carl Andrew. 2000

机译：小鼠BCG疫苗接种的免疫学：对结核疫苗的接种以及BCG作为重组疫苗载体的用途。
6. Immunogenicity of a Bivalent Non-Purified Recombinant Vaccine against Botulism in Cattle [O] . Clóvis Moreira Jr., Marcos R. A. Ferreira, Carlos E. P. da Cunha, 2018

机译：二价非纯化重组牛肉毒杆菌的免疫原性。
7. Inflammatory response of feedlot cattle to clostridial vaccination: a comparison of 7-way bacterin-toxoid and CD toxoid [O] . Gerald L. Stokka, Robert T. Brandt, A.J. Edwards, 1993

机译：Feedlot牛对梭菌疫苗接种的炎症反应：7型菌毒类毒素和C＆D无毒的比较

Vaccination of cattle with a recombinant bivalent toxoid against botulism serotypes C and D.

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