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首页> 外文期刊>Vaccine >Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine in adults 18-49 years of age, naive to 23-valent pneumococcal polysaccharide vaccine
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Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine in adults 18-49 years of age, naive to 23-valent pneumococcal polysaccharide vaccine

机译:初次接种23价肺炎球菌多糖疫苗的18-49岁成人13价肺炎球菌结合疫苗的免疫原性和安全性

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Background: Based on the success of vaccination with pneumococcal conjugate vaccines (PCVs) in children, recent studies have focused on PCVs in adults. Data from a randomized, double-blind study comparing the immunogenicity, tolerability, and safety of the 13-valent PCV (PCV13) and the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in PPSV23-naive adults 60-64 years of age have been published. The same study also included a cohort of adults aged 18-49 years that received open-label PCV13. The purpose of this cohort was to examine the immunogenicity, safety, and tolerability of PCV13 in adult subjects 18-49 years of age compared with adults 60-64 years of age for whom PCV13 is approved.
机译:背景:基于在儿童中成功接种肺炎球菌结合疫苗(PCV)的经验,最近的研究集中于成人的PCV。来自一项随机双盲研究的数据,该数据比较了在60-64岁的未出生PPSV23的成年人中13价PCV(PCV13)和23价肺炎球菌多糖疫苗(PPSV23)的免疫原性,耐受性和安全性发表。这项研究还包括接受开放标签PCV13的18-49岁成年人群。该队列的目的是检查与批准PCV13的60-64岁成年人相比,PCV13在18-49岁的成年人受试者中的免疫原性,安全性和耐受性。

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