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首页> 外文期刊>Vaccine >Porcine reproductive and respiratory syndrome virus (PRRSv) modified-live vaccine reduces virus transmission in experimental conditions
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Porcine reproductive and respiratory syndrome virus (PRRSv) modified-live vaccine reduces virus transmission in experimental conditions

机译：猪繁殖与呼吸综合征病毒（PRRSv）改良活疫苗可减少实验条件下的病毒传播

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Some vaccination strategies have shown good results in reducing the clinical outcomes of PRRS. Nevertheless the effect of vaccines on viral transmission is poorly described, so we aimed to fill this gap with the present study. Twelve Specific Pathogen Free (SPF) piglets, vaccinated against PRRSv at 3 weeks of age (Porcilis PRRS ID (R), MSD), were inoculated at 31 days post-vaccination with a heterologous genogroup 1.1 strain, and put in contact with 12 vaccinated piglets during 49 days. The same protocol was carried out simultaneously with SPF non-vaccinated piglets. Piglets were monitored individually for clinical symptoms on a daily basis and individual blood samples were taken twice a week. In inoculated piglets, the genome viral load specific to the inoculated strain was reduced and viraemia shortened in vaccinated piglets (28 days versus 38 days in non vaccinated piglets). In contact pigs, the challenge strain was detected in the serum of only one vaccinated piglet whereas it was detected in all contact non-vaccinated piglets. Transmission parameters were estimated by a Bayesian analysis of transmission data in the two groups. The estimated transmission rate was 10-times lower in vaccinated than in non-vaccinated piglets and the duration of infectiousness was reduced, leading to a reproduction ratio R significantly lower (0.30 [0.05-0.96] versus 5.42 [2.94-9.04] in non vaccinated piglets). Hence, in our experimental conditions, vaccination was able to decrease considerably PRRSv spread. A complementary evaluation in field conditions would be required to identify circumstances associated with infection control failures that can be, observed in pig farms. (C) 2015 Elsevier Ltd. All rights reserved.
机译：一些疫苗接种策略在减少PRRS的临床结局方面显示出良好的效果。然而，疫苗对病毒传播的作用描述不清，因此我们旨在通过本研究填补这一空白。接种后第31天，在异种基因组1.1菌株中接种12只3周龄时针对PRRSv接种的特定无病原体（SPF）仔猪（Porcilis PRRS ID（R），MSD），并与12种接种疫苗接触仔猪在49天内。对未接种SPF的仔猪同时进行相同的实验方案。每天单独监测仔猪的临床症状，每周两次采集单独的血样。在接种的仔猪中，接种的仔猪的基因组病毒特异性载量降低，病毒血症缩短（28天相比未接种的仔猪38天）。在接触猪中，仅在一只接种疫苗的仔猪的血清中检测到了挑战菌株，而在所有接触未接种疫苗的仔猪中均检测到了该菌株。通过两组的传输数据的贝叶斯分析来估计传输参数。接种疫苗的估计传播率比未接种疫苗的仔猪低10倍，传染性持续时间减少，从而导致繁殖率R显着降低（未接种疫苗的仔猪的繁殖率R降低（0.30 [0.05-0.96]比5.42 [2.94-9.04]）小猪）。因此，在我们的实验条件下，接种疫苗能够大大减少PRRSv的传播。需要在田间条件下进行补充评估，以确定与在猪场中观察到的感染控制失败有关的情况。 （C）2015 Elsevier Ltd.保留所有权利。

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