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Genetic diversity and population dynamics of Bordetella pertussis in China between 1950-2007

机译：1950-2007年中国百日咳博德特氏菌的遗传多样性和种群动态

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Pertussis is an acute respiratory infectious disease caused by the bacterium Bordetella pertussis. Although pertussis vaccination was introduced in the 1960s, pertussis is still an endemic disease in China. To better understand the genetic diversity of the Chinese B. pertussis population, we characterized 115 clinical isolates obtained in China during 1950-2007 using multilocus variable-number tandem repeat analysis (MLVA). Forty-six different B. pertussis MLVA profiles (MTs) were identified, of which 13 were new MTs. Analysis using a minimum-spanning tree showed that distinct MTs were prevalent during different periods, suggesting that a dynamic change in B. pertussis MTs occurred over time in China. The predominant MTs in recent isolates from China were different from those of many developed countries. A decreasing trend in genetic diversity of the B. pertussis population was observed following the introduction of pertussis vaccines. Similar to the pertactin 2 (prn2) allele, the novel pertussis toxin promoter (ptxP3) allele first emerged in 2000, but unlike trends elsewhere, ptxP1 remained predominant among the isolates, further reflecting the unique temporal trends in the B. pertussis population in China. Our results suggest that temporal changes in the B. pertussis population may be closely associated with vaccination coverage and the vaccine types used. These data may lead to an improved understanding of the virulence mechanism of B. pertussis and facilitate new strategies for controlling this infectious disease. (C) 2015 Elsevier Ltd. All rights reserved.
机译：百日咳是由百日咳博德特氏菌引起的急性呼吸道传染病。尽管百日咳疫苗是在1960年代引入的，但百日咳仍是中国的地方病。为了更好地了解百日咳博德特氏菌种群的遗传多样性，我们使用多基因座可变数串联重复分析（MLVA）对1950-2007年在中国获得的115株临床分离株进行了特征分析。鉴定了46种不同的百日咳博德特氏菌MLVA图谱（MTs），其中13种是新的MTs。使用最小生成树进行的分析显示，不同时期的MT普遍存在，这表明百日咳博德特氏菌MT随时间动态变化。最近来自中国的分离株中主要的MT与许多发达国家的MT不同。引入百日咳疫苗后，观察到百日咳博德特氏菌种群遗传多样性下降。与pertactin 2（prn2）等位基因相似，新型百日咳毒素启动子（ptxP3）等位基因于2000年首次出现，但与其他趋势不同的是，ptxP1在分离株中仍占主导地位，进一步反映了中国百日咳杆菌的独特时间趋势。 。我们的结果表明，百日咳博德特氏菌种群的时间变化可能与疫苗接种覆盖率和所用疫苗类型密切相关。这些数据可能导致人们更好地了解百日咳博德特氏菌的毒力机制，并有助于控制这种传染病的新策略。 （C）2015 Elsevier Ltd.保留所有权利。

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