Production of high titer attenuated poliovirus strains on the serum-free PER.C6 (R) cell culture platform for the generation of safe and affordable next generation IPV

Sanders Barbara P.; Oakes Isabel de Los Rios; van Hoek Vladimir; Liu Ying; Marissen Wilfred; Minor Philip D.; Wimmer Eckard; Schuitemaker Hanneke; Custers Jerome H. H. V.; Macadam Andrew; Cello Jeronimo; Edo-Matas Diana

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Production of high titer attenuated poliovirus strains on the serum-free PER.C6 (R) cell culture platform for the generation of safe and affordable next generation IPV

机译：在无血清的PER.C6（R）细胞培养平台上生产高滴度的脊髓灰质炎病毒减毒株，用于生成安全且负担得起的下一代IPV

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Background: As poliovirus eradication draws closer, alternative Inactivated Poliovirus Vaccines (IPV) are needed to overcome the risks associated with continued use of the Oral Poliovirus Vaccine and of neurovirulent strains used during manufacture of conventional (c) IPV. We have previously demonstrated the susceptibility of the PER.C6 (R) cell line to cIPV strains; here we investigated the suspension cell culture platform for growth of attenuated poliovirus strains.

机译：背景：随着消灭脊髓灰质炎病毒的日益临近，需要使用替代的灭活脊髓灰质炎疫苗（IPV）来克服与持续使用口服脊髓灰质炎病毒疫苗和在常规（c）IPV生产过程中使用的神经毒性毒株相关的风险。先前我们已经证明PER.C6（R）细胞系对cIPV株具有敏感性。在这里，我们研究了减毒脊髓灰质炎病毒株生长的悬浮细胞培养平台。

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《Vaccine》 |2015年第48期|共6页
作者
Sanders Barbara P.; Oakes Isabel de Los Rios; van Hoek Vladimir; Liu Ying; Marissen Wilfred; Minor Philip D.; Wimmer Eckard; Schuitemaker Hanneke; Custers Jerome H. H. V.; Macadam Andrew; Cello Jeronimo; Edo-Matas Diana;
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正文语种 eng
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Poliovirus; PER.C6 (R) cells; Next generation IPV; Sabin; Rationally-attenuated strains; Vaccines;

机译：脊髓灰质炎病毒;PER.C6（R）细胞;下一代IPV;Sabin;理性减毒株;疫苗;

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1. Production of high titer attenuated poliovirus strains on the serum-free PER.C6 (R) cell culture platform for the generation of safe and affordable next generation IPV [J] . Sanders Barbara P., Oakes Isabel de Los Rios, van Hoek Vladimir, Vaccine . 2015,第48期

机译：在无血清的PER.C6（R）细胞培养平台上生产高滴度的脊髓灰质炎病毒减毒株，用于生成安全且负担得起的下一代IPV
2. An inactivated poliovirus vaccine using Sabin strains produced on the serum-free PER.C6? cell culture platform is immunogenic and safe in a non-human primate model [J] . Viki Bockstal, Machteld M. Tiemessen, Rogier Achterberg, Vaccine . 2018,第46期

机译：使用Sabin菌株在无血清中产生的灭活脊髓灰质病毒疫苗αC6？细胞培养平台在非人灵长类动物模型中是免疫原性和安全的
3. An inactivated poliovirus vaccine using Sabin strains produced on the serum-free PER.C6? cell culture platform is immunogenic and safe in a non-human primate model [J] . Viki Bockstal, Machteld M. Tiemessen, Rogier Achterberg, Vaccine . 2018,第46期

机译：使用Sabin菌株在无血清中产生的灭活脊髓灰质病毒疫苗αC6？细胞培养平台在非人灵长类动物模型中是免疫原性和安全的
4. BI HEX~(TM) - Platform for Fast Track Generation of High Producer Cell Lines Leading to High-Titer Processes for Production of Therapeutic Proteins from Mammalian Cells [C] . Torsten W. Schulz, Stefan Schlatter, Hitto Kaufmann, European Society of Animal Cell Technology . 2010

机译：BI Hex〜（TM） - 快速轨道生成高生产电平细胞系的平台，导致来自哺乳动物细胞的治疗蛋白质的高滴度工艺
5. Generation and characterization of an attenuated mutant in a response-regulator gene of Francisella tularensis live vaccine strain (LVS). [D] . Sammons, Wendy L. 2007

机译：图拉弗朗西斯菌活疫苗株（LVS）的应答调节基因中减毒突变体的产生和表征。
6. An inactivated poliovirus vaccine using Sabin strains produced on the serum-free PER.C6® cell culture platform is immunogenic and safe in a non-human primate model [O] . Viki Bockstal, Machteld M. Tiemessen, Rogier Achterberg, -1

机译：使用在无血清PER.C6®细胞培养平台上生产的Sabin菌株灭活的脊髓灰质炎病毒疫苗在非人类灵长类动物模型中具有免疫原性和安全性
7. Generation of a high-titer packaging cell line for the production of retroviral vectors in suspension and serum-free media [O] . Ghani, K., Cottin, S., Kamen, A., 2007

机译：用于在悬浮液和无血清培养基中生产逆转录病毒载体的高滴度包装细胞系的产生

Production of high titer attenuated poliovirus strains on the serum-free PER.C6 (R) cell culture platform for the generation of safe and affordable next generation IPV

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