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Immune overload: Parental attitudes toward combination and single antigen vaccines

机译：免疫超负荷：父母对联合和单抗原疫苗的态度

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Parental concerns have led to a recent decline in immunization coverage, resulting in outbreaks of diseases that were once under control in the US. As the CDC vaccination schedule continues to increase in complexity, the number of required injections per office visit increases as well. Some parents perceive that there is trauma associated with the administration of multiple injections, and research shows that having multiple vaccines due in a single visit is associated with delays and lower immunization rates. Combination vaccines make vaccination more efficient by incorporating the antigens of several different diseases into a single injection, but many parents worry that they may overload the child's developing immune system and leave him or her susceptible to secondary infections. This literature review synthesizes current evidence regarding the parental fear of vaccine-induced immune system overload and the fear of vaccine-associated trauma, in an attempt to understand the scope and nature of these fears. Despite the wealth of knowledge about each of these fears individually, it is still unknown which is of greater concern and how this affects parental decision-making. (C) 2015 Elsevier Ltd. All rights reserved.
机译：父母的担忧导致近期免疫覆盖率下降，导致曾经在美国受到控制的疾病暴发。随着CDC疫苗接种计划日趋复杂，每次办公室就诊所需的注射次数也在增加。一些父母认为多次注射会带来创伤，研究表明，单次就诊需要多次注射疫苗会导致延误和降低免疫率。组合疫苗通过将几种不同疾病的抗原整合到一次注射中而使疫苗接种更加有效，但是许多父母担心，它们可能会使孩子不断发展的免疫系统超负荷，并使他或她容易受到继发感染。该文献综述综合了有关父母对疫苗引起的免疫系统超负荷的恐惧以及对疫苗相关创伤的恐惧的当前证据，以试图理解这些恐惧的范围和性质。尽管对每种恐惧都有各自的知识，但仍需进一步研究的问题仍然是未知的，这又如何影响父母的决策。 （C）2015 Elsevier Ltd.保留所有权利。

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