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首页> 外文期刊>Vaccine >Interchangeability of meningococcal group C conjugate vaccines with different carrier proteins in the United Kingdom infant immunisation schedule
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Interchangeability of meningococcal group C conjugate vaccines with different carrier proteins in the United Kingdom infant immunisation schedule

机译：英国婴幼儿免疫计划中脑膜炎球菌C群结合疫苗与不同载体蛋白的互换性

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An open, non-randomised study was undertaken in England during 2011-12 to evaluate vaccine antibody responses in infants after completion of the routine primary infant immunisation schedule, which included two doses of meningococcal group C (MenC) conjugate (MCC) vaccine at 3 and 4 months. Any of the three licensed MCC vaccines could be used for either dose, depending on local availability. Healthy term infants registered at participating general practices (GPs) in Hertfordshire and Gloucestershire, UK, were recruited prospectively to provide a single blood sample four weeks after primary immunisation, which was administered by the GP surgery. Vaccination history was obtained at blood sampling. MenC serum bactericidal antibody (SBA) and IgG antibodies against Haemophilus influenzae b (Hib), pertussis toxin (PT), diphtheria toxoid (DT), tetanus toxoid (TT) and thirteen pneumococcal serotypes were analysed according to MCC vaccines received. MenC SBA responses differed significantly (P 0.001) according to MCC vaccine schedule as follows: MenC SBA geometric mean titres (GMTs) were significantly lower in infants receiving a diphtheria cross-reacting material-conjugated MCC (MCC-CRM) vaccine followed by TT-conjugated MCC (MCC-TT) vaccine (82.0; 95% CI, 39-173; n = 14) compared to those receiving two MCC-CRM (418; 95% Cl, 325-537; n = 82), two MCC-TT (277; 95% CI, 223-344; n = 79) or MCC-TT followed by MCC-CRM (553; 95% CI, 322-949; n = 18). The same group also had the lowest Hib geometric mean concentrations (0.60 mu g/mL, 0.27-1.34) compared to 1.85 mu g/mL (1.23-2.78), 2.86 mu g/mL (2.02-4.05) and 4.26 mu g/mL (1.94-9.36), respectively. Our results indicate that MCC vaccines with different carrier proteins are not interchangeable. When several MCC vaccines are available, children requiring more than one dose should receive MCC vaccines with the same carrier protein or, alternatively, receive MCC-TT first wherever possible. (C) 2014 Elsevier Ltd. All rights reserved.
机译：在2011-12年间，英国进行了一项开放，非随机的研究，以评估常规的初次婴儿免疫接种计划完成后婴儿的疫苗抗体反应，其中包括在3岁时接种两剂C型脑膜炎球菌C（MenC）结合物（MCC）和4个月。根据当地情况，三种许可的MCC疫苗中的任何一种都可以使用两种剂量。前瞻性招募了在英国赫特福德郡和格洛斯特郡参加参与常规活动（GP）的健康足月婴儿，以在初次免疫后四周提供一次血液样本，并通过GP手术进行管理。在采血时获得了疫苗接种史。根据收到的MCC疫苗分析了针对流感嗜血杆菌b（Hib），百日咳毒素（PT），白喉类毒素（DT），破伤风类毒素（TT）和13种肺炎球菌血清型的MenC血清杀菌抗体（SBA）和IgG抗体。根据MCC疫苗时间表，MenC SBA反应显着不同（P <0.001）：在接受白喉交叉反应物质结合MCC（MCC-CRM）疫苗和TT的婴儿中，MenC SBA几何平均滴度（GMT）显着降低-结合的MCC（MCC-TT）疫苗（82.0; 95％CI，39-173; n = 14），而接受两种MCC-CRM（418; 95％Cl，325-537; n = 82），两种MCC -TT（277; 95％CI，223-344; n = 79）或MCC-TT，然后依次是MCC-CRM（553; 95％CI，322-949; n = 18）。同一组的Hib几何平均浓度也最低（0.60μg/ mL，0.27-1.34），而1.85μg/ mL（1.23-2.78），2.86μg/ mL（2.02-4.05）和4.26μg/ mL mL（1.94-9.36）。我们的结果表明，带有不同载体蛋白的MCC疫苗是不可互换的。如果有几种MCC疫苗可供使用，则需要多于一剂的儿童应接种具有相同载体蛋白的MCC疫苗，或者尽可能先接种MCC-TT。 （C）2014 Elsevier Ltd.保留所有权利。

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