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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Superparamagnetic iron oxide nanoparticles stabilized by a poly(amidoamine)-rhenium complex as potential theranostic probe
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Superparamagnetic iron oxide nanoparticles stabilized by a poly(amidoamine)-rhenium complex as potential theranostic probe

机译：聚（ami胺）-complex配合物稳定的超顺磁性氧化铁纳米颗粒作为潜在的治疗探针

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摘要

Three-component nanocomposites, constituted by a superparamagnetic iron oxide core coated with a polymeric surfactant bearing tightly bound Re(CO)_3 moieties, were prepared and fully characterized. The water soluble and biocompatible surfactant was a linear poly(amidoamine) copolymer (PAA), containing cysteamine pendants in the minority part (ISA23SH), able to coordinate Re(CO)_3 fragments. For the synthesis of the nanocomposites two methods were compared, involving either (i) peptization of bare magnetite nanoparticles by interaction with the preformed ISA23SH-Re(CO)_3 complex, or (ii) "one-pot" synthesis of iron oxide nanoparticles in the presence of the ISA23SH copolymer, followed by complexation of Re to the SPIO@ISA23SH nanocomposite. Full characterization by TEM, DLS, TGA, SQUID, and relaxometry showed that the second method gave better results. The magnetic cores had a roundish shape, with low dispersion (mean diameter ca. 6 nm) and a tendency to form larger aggregates (detected both by TEM and DLS), arising from multiple interactions of the polymeric coils. Aggregation did not affect the stability of the nano-suspension, found to be stable for many months without precipitate formation. The SPIO@PAA-Re nanoparticles (NPs) showed superparamagnetic behaviour and nuclear relaxivities similar or superior to commercial MRI contrast agents (CAs), which make them promising as MRI "negative" CAs. The possibility to encapsulate ~(186/188)Re isotopes (γ and β emitters) gives these novel NPs the potential to behave as bimodal nanostructures devoted to theranostic applications.
机译：制备了三组分纳米复合材料，该复合物由包覆有带有紧密结合的Re（CO）_3部分的聚合物表面活性剂的超顺磁性氧化铁核构成，并得到了充分表征。水溶性和生物相容性表面活性剂是线性聚（酰胺基胺）共聚物（PAA），在少数部分（ISA23SH）含有半胱胺侧基，能够配位Re（CO）_3片段。对于纳米复合材料的合成，比较了两种方法，包括：（i）通过与预先形成的ISA23SH-Re（CO）_3配合物相互作用来胶溶裸露的磁铁矿纳米颗粒，或（ii）通过“一锅法”合成氧化铁纳米颗粒。 ISA23SH共聚物的存在，然后将Re络合至SPIO @ ISA23SH纳米复合材料。通过TEM，DLS，TGA，SQUID和弛豫法进行的全面表征表明，第二种方法给出了更好的结果。磁芯呈圆形，分散度低（平均直径约6 nm），并且由于聚合物线圈的多次相互作用而形成较大的聚集体（通过TEM和DLS检测）。聚集没有影响纳米悬浮液的稳定性，发现该纳米悬浮液可以稳定许多个月而不会形成沉淀。 SPIO @ PAA-Re纳米粒子（NPs）具有超顺磁行为和核弛豫性，与商业MRI造影剂（CA）相似或更好，这使其有望成为MRI“阴性”CA。封装〜（186/188）Re同位素（γ和β发射体）的可能性使这些新颖的NP表现出了作为双峰纳米结构的潜能，可用于治疗学应用。

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