New palladium(II) and platinum(II) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2 '-bipyridine and 2,2 '-dipyridylamine: synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity

Icsel Ceyda; Yilmaz Veysel T.; Kaya Yunus; Samli Hale; Harrison William T. A.; Buyukgungor Orhan

首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >New palladium(II) and platinum(II) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2 '-bipyridine and 2,2 '-dipyridylamine: synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity

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New palladium(II) and platinum(II) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2 '-bipyridine and 2,2 '-dipyridylamine: synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity

机译：新的5,5-二乙基巴比妥酸钯（II）和铂（II）与2-苯基吡啶，2,2'-联吡啶和2,2'-二吡啶胺的络合物：合成，结构，DNA结合，分子对接，细胞吸收，抗氧化活性和细胞毒性

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Novel palladium(II) and platinum(II) complexes of 5,5-diethylbarbiturate (barb) with 2-phenylpyridine (Hppy), 2,2'-bipyridine (bpy) and 2,2'-dipyridylamine (dpya) have been prepared and characterized by elemental analysis, IR, UV-Vis, NMR and ESI-MS. Single-crystal diffraction measurements show that complex 1 consists of binuclear [Pd-2(mu-barb-kappa N,O)(2)(ppy-kappa N,C)(2)] moieties, while complexes 3-5 are mononuclear, [M(barb-.kappa)(2)(L-kappa N,N')] (L = bpy or dpya). 6 has a composition of [Pt(dpya-kappa N,N')(2)][Ag(barb-kappa N)(2)](2)center dot 4H(2)O and 2 was assumed to have a structure of [Pt(barb-kappa N)(Hppy-kappa N)(ppy-kappa N,C)]center dot 3H(2)O. The complexes were found to exhibit significant DNA binding affinity by a non-covalent binding mode, in accordance with molecular docking studies. In addition, complexes 1 and 2 displayed strong binding with supercoiled pUC19 plasmid DNA. Cellular uptake studies were performed to assess the subcellular localization of the selected complexes. A moderate radical scavenging activity of 1 and 2 was confirmed by DPPH and ABTS tests. Complexes 1, 2, and 5 showed selectivity against HT-29 (colon) cell line.

机译：制备了5,5-二乙基巴比妥酸酯（倒钩）与2-苯基吡啶（Hppy），2,2'-联吡啶（bpy）和2,2'-联吡啶胺（dpya）的新型钯（II）和铂（II）配合物并通过元素分析，IR，UV-Vis，NMR和ESI-MS进行表征。单晶衍射测量表明，配合物1由双核[Pd-2（mu-barb-kappa N，O）（2）（ppy-kappa N，C）（2）]部分组成，而配合物3-5为单核。，[M（barb-.kappa）（2）（L-kappa N，N'）]（L = bpy或dpya）。图6具有[Pt（dpya-kappa N，N'）（2）] [Ag（倒钩-kappa N）（2）]（2）中心点4H（2）O的组成，并且假设2具有结构中心点3H（2）O的[Pt（倒钩-κN）（Hppy-κN）（ppy-kappa N，C）]的中心。根据分子对接研究，发现该复合物通过非共价结合模式表现出显着的DNA结合亲和力。另外，复合物1和2显示出与超螺旋的pUC19质粒DNA的强结合。进行细胞摄取研究以评估所选复合物的亚细胞定位。 DPPH和ABTS测试确认了1和2的中等自由基清除活性。配合物1、2和5对HT-29（结肠）细胞系表现出选择性。

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《Dalton transactions: An international journal of inorganic chemistry》 |2015年第15期|共16页
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Icsel Ceyda; Yilmaz Veysel T.; Kaya Yunus; Samli Hale; Harrison William T. A.; Buyukgungor Orhan;
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1. New palladium(II) and platinum(II) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2 '-bipyridine and 2,2 '-dipyridylamine: synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity [J] . Icsel Ceyda, Yilmaz Veysel T., Kaya Yunus, Dalton transactions: An international journal of inorganic chemistry . 2015,第15期

机译：新的5,5-二乙基巴比妥酸钯（II）和铂（II）与2-苯基吡啶，2,2'-联吡啶和2,2'-二吡啶胺的络合物：合成，结构，DNA结合，分子对接，细胞吸收，抗氧化活性和细胞毒性
2. Synthesis, structures, DNA/protein binding, molecular docking, anticancer activity and ROS generation of Ni(II), Cu(II) and Zn(II) 5,5-diethylbarbiturate complexes with bis(2-pyridylmethyl) amine and terpyridine [J] . Yilmaz Veysel T., Icsel Ceyda, Suyunova Feruza, New Journal of Chemistry . 2017,第16期

机译：Ni（II），Cu（II）和Zn（II）的合成，结构，DNA /蛋白结合，分子对接，抗癌活性和ROS生成与双（2-吡啶甲基）胺和萜烯酮（II）5,5-二乙基巴比特复合物。
3. Synthesis, characterization, DNA binding and cytotoxic studies of platinum(II) and palladium(II) complexes of the 2,2'-bipyridine and an anion of 1,1-cyclobutanedicarboxylic acid. [J] . Mansuri-Torshizi H, Ghadimy S, Akbarzadeh N Chemical and Pharmaceutical Bulletin . 2001,第12期

机译：2,2'-联吡啶和1,1-环丁烷二羧酸阴离子的铂（II）和钯（II）配合物的合成，表征，DNA结合和细胞毒性研究。
4. Synthesis and Characterization of the Monomeric Platinum (II) Complexes with 2,2'-Bipyridine Back-bone Ligand [C] . Minchul Chung, Woong Kyu Jo, Seak Hwan Son, International Conference on Chemical Engineering and Advanced Materials . 2012

机译：用2,2'-硼吡啶背骨配体的单体铂（II）配合物的合成与表征
5. The synthesis of mono-substituted disulfide-functionalized 2,2'-bipyridines and the corresponding tris(2,2'-bipyridine)ruthenium(II) complexes for self-assembled monolayers. [D] . Kumpaty, Hephzibah Jayasheela. 1996

机译：用于自组装单层的单取代二硫键官能化的2,2'-联吡啶和相应的三（2,2'-联吡啶）钌（II）配合物的合成。
6. (2,2′-Bipyridine-κ2N,N′)diiodidopalladium(II) [O] . Kwang Ha 2016

机译：（2,2'-联吡啶-κ2N，N'）二碘钯（II）
7. New palladium(II) and platinum(II) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2’-bipyridine and 2,2’-dipyridylamine : synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity [O] . Icsel, Ceyda, Yilmaz, Veysel T., Kaya, Yunus, 2015

机译：新的5,5-二乙基巴比妥酸钯（II）和铂（II）与2-苯基吡啶，2,2'-联吡啶和2,2'-二吡啶胺的络合物：合成，结构，DNA结合，分子对接，细胞吸收，抗氧化活性和细胞毒性
8. Unique Spectroscopic Properties of Mixed-Ligand Complexes with 2,2'-Dipyridylamine: A Dual Luminescence from a Ruthenium(II) Complex [R] . Blakley, R. L., DeArmond, M. K. 1987

机译：具有2,2'-二吡啶胺的混合配体配合物的独特光谱性质：来自钌（II）配合物的双重发光

New palladium(II) and platinum(II) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2 '-bipyridine and 2,2 '-dipyridylamine: synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity

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