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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Carbohydrate-appended photocytotoxic (imidazophenanthroline)-oxovanadium(IV) complexes for cellular targeting and imaging
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Carbohydrate-appended photocytotoxic (imidazophenanthroline)-oxovanadium(IV) complexes for cellular targeting and imaging

机译：碳水化合物附加的光细胞毒性（咪唑并菲咯啉）-氧钒（IV）复合物用于细胞靶向和成像

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摘要

Oxovanadium(IV) complexes [VO(aip)(L)](ClO_4)_2 (L = phtpy, 1; stpy, 2) and [VO(pyip)(L)](ClO_4)_2 (L = phtpy, 3; stpy, 4), where aip is 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline, pyip is [2-(1-pyrenyl)-1Himidazo[4,5-f][1,10]phenanthroline, phtpy is (4'-phenyl)-2,2':6',2"-terpyridine and stpy is (2,2':6',2"-terpyridin- 4'-oxy)ethyl-β-D-glucopyranoside, were prepared, characterized and their DNA binding and photocleavage activity, cellular uptake and photocytotoxicity in visible light were studied. The complexes are avid binders to calf thymus DNA (Kb ~10~5 mol~(-1)). They efficiently cleave pUC19 DNA in red light of 705 nm via the formation of HO? species. The glucose appended complexes 2 and 4 showed higher photocytotoxicity in HeLa and Hep G2 cells over the normal HEK 293T cells. No such preference was observed for the phtpy complexes 1 and 3. No significant difference in IC_(50) values was observed for the HEK 293T cells. Cell cycle analysis showed that the glucose appended complexes 2 and 4 are more photocytotoxic in cancer cells than in normal cells. Fluorescence microscopy was done to study the cellular localization of complex 4 having a pendant pyrenyl group.
机译：氧钒（IV）络合物[VO（aip）（L）]（ClO_4）_2（L = phtpy，1; stpy，2）和[VO（pyip）（L）]（ClO_4）_2（L = phtpy，3; stpy，4），其中aip是2-（9-蒽基）-1H-咪唑并[4,5-f] [1,10]菲咯啉，pyip是[2-（1-pyrenyl）-1Himidazo [4,5- f] [1,10]菲咯啉，pptpy是（4'-苯基）-2,2'：6'，2“-叔吡啶，stpy是（2,2'：6'，2”-叔吡啶-4'-制备并表征了氧）乙基-β-D-吡喃葡萄糖苷的含量，并研究了它们在可见光下的DNA结合和光裂解活性，细胞摄取和光细胞毒性。该复合物是小牛胸腺DNA（Kb〜10〜5 mol〜（-1））的狂热结合物。他们通过形成HO ?，有效地在705 nm的红光中裂解pUC19 DNA。种类。葡萄糖附加复合物2和4在HeLa和Hep G2细胞中显示出比正常HEK 293T细胞更高的光细胞毒性。对于pptpy复合物1和3没有观察到这样的偏好。对于HEK 293T细胞，没有观察到IC_（50）值的显着差异。细胞周期分析表明，与癌细胞相比，葡萄糖附加复合物2和4在癌细胞中的光细胞毒性更大。进行荧光显微镜检查以研究具有侧基pyr基的配合物4的细胞定位。

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