Tuning the coordination properties of phenothiazine by regioselective introduction of diphenylphosphanyl groups

Filip I. H.; Gal E.; Lupan I.; Perde-Schrepler M.; Loennecke P.; Surducan M.; Gaina L. I.; Hey-Hawkins E.; Silaghi-Dumitrescu L.

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Tuning the coordination properties of phenothiazine by regioselective introduction of diphenylphosphanyl groups

机译：通过区域选择性引入二苯基膦酰基调节吩噻嗪的配位性能

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The palladium and platinum complexes of the newly synthesized 1-(diphenylphosphino)-10-methyl-10H-phenothiazine (1) and the previously reported 3-(diphenylphosphino)-10-alkyl-10H-phenothiazine [alkyl = Me (2), Et (3)] and 4-(diphenylphosphino)-10-ethyl-10H-phenothiazine (4) were prepared. Density functional calculations were carried out to explain the electronic properties of compounds 1, 3 and 4. Compounds 1, 3 and 4 can interact with DNA, as was observed in agarose gel electrophoresis experiments. In addition, the cytotoxicity of the platinum complexes of ligands 2 and 4 towards breast, colorectal and hepatocarcinoma cell lines was studied.

机译：新合成的1-（二苯基膦基）-10-甲基-10H-吩噻嗪（1）和先前报道的3-（二苯基膦基）-10-烷基-10H-吩噻嗪[烷基= Me（2），制备[Et（3）]和4-（二苯基膦基）-10-乙基-10H-吩噻嗪（4）。如在琼脂糖凝胶电泳实验中所观察到的，进行密度泛函计算以解释化合物1、3和4的电子性质。化合物1、3和4可以与DNA相互作用。此外，还研究了配体2和4的铂配合物对乳腺癌，结肠直肠癌和肝癌细胞系的细胞毒性。

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《Dalton transactions: An international journal of inorganic chemistry》 |2015年第2期|共15页
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Filip I. H.; Gal E.; Lupan I.; Perde-Schrepler M.; Loennecke P.; Surducan M.; Gaina L. I.; Hey-Hawkins E.; Silaghi-Dumitrescu L.;
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1. Tuning the coordination properties of phenothiazine by regioselective introduction of diphenylphosphanyl groups [J] . Filip I. H., Gal E., Lupan I., Dalton transactions: An international journal of inorganic chemistry . 2015,第2期

机译：通过区域选择性引入二苯基膦酰基调节吩噻嗪的配位性能
2. Tuning of the Coordination and Emission Properties of 4-Amino-2,1,3-Benzothiadiazole by Introduction of Diphenylphosphine Group [J] . Sukhikh Taisiya S., Khisamov Radmir M., Bashirov Denis A., Crystal growth & design . 2020,第9期

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3. Preparation, coordination properties and catalytic use of l'-(diphenylphosphanyl)-1-ferrocenecarboxamides bearing 2-hydroxyethyl pendant groups [J] . Ji_í Schulz, Ivana Císa_ová, Petr _těpni_ka Journal of Organometallic Chemistry . 2009,第15期

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4. Silica gel-assisted preparation of multihalo-benzobthiophenes and its application to regioselective introduction of substituents [C] . Shinichi Mikami, Hiroki Tanaka, Hiroki Kishi 日本化学会春季年会講演予稿集 . 2018

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5. Effect of iron-nitrogen coordination (type II binding) on drug metabolism by cytochrome p450: Studies to understand the kinetics, metabolic stability and regioselectivity. [D] . Dahal, Upendra Purush. 2012

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6. Bimetallic nickel-lutetium complexes: tuning the properties and catalytic hydrogenation activity of the Ni site by varying the Lu coordination environment [O] . Bianca L. Ramirez, Prachi Sharma, Reed J. Eisenhart, 2019

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Tuning the coordination properties of phenothiazine by regioselective introduction of diphenylphosphanyl groups

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