Cobaltoceniumethynyl gold(I) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes

Vanicek S.; Kopacka H.; Wurst K.; Vergeiner S.; Kankowski S.; Schur J.; Bildstein B.; Ott I.

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Cobaltoceniumethynyl gold(I) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes

机译：钴乙炔基金（I）作为不寻常的异核生物金属金属片段，用于研究炔基金配合物的生物学特性

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A cobaltoceniumethynyl gold(I) complex with a triphenylphosphane ligand triggered efficient cytotoxic effects in cancer cells in contrast to a derivative with two cobaltocenium moieties. The complex effectively inhibited the enzyme thioredoxin reductase (TrxR) suggesting this enzyme as a possible biological target. The cellular uptake of both metal fragments of the active complex was studied by atomic absorption spectroscopy and indicated a high biological stability of the complex.

机译：与具有两个钴ce部分的衍生物相反，具有三苯基膦配体的钴ce乙炔基金（I）络合物在癌细胞中引发有效的细胞毒性作用。该复合物有效抑制了硫氧还蛋白还原酶（TrxR），表明该酶可能是生物学目标。通过原子吸收光谱法研究了活性复合物的两个金属片段的细胞摄取，表明该复合物具有很高的生物稳定性。

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《Dalton transactions: An international journal of inorganic chemistry》 |2016年第4期|共4页
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Vanicek S.; Kopacka H.; Wurst K.; Vergeiner S.; Kankowski S.; Schur J.; Bildstein B.; Ott I.;
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1. Cobaltoceniumethynyl gold(I) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes [J] . Vanicek S., Kopacka H., Wurst K., Dalton transactions: An international journal of inorganic chemistry . 2016,第4期

机译：钴乙炔基金（I）作为不寻常的异核生物金属金属片段，用于研究炔基金配合物的生物学特性
2. Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold(I) complexes featuring N-heterocyclic carbene and alkynyl ligands [J] . Journal of Inorganic Biochemistry: An Interdisciplinary Journal . 2020,第期

机译：对比较生物学评价和G-Quadreplex相互作用研究，其两个新的有机金属金（I）复合物具有N-杂环甲苯和炔基配体的组合物
3. Study of the effect of the chromophore and nuclearity on the aggregation and potential biological activity of gold(I) alkynyl complexes [J] . Gavara Raquel, Aguilo Elisabet, Schur Julia, Inorganica Chimica Acta . 2016,第Null期

机译：发色团和原子核对金（I）炔基配合物的聚集和潜在生物活性的影响研究
4. Biological solvents of silver and gold: Their complexes in process of preparation of colloidal silver and liquid gold [C] . V.K.Larin, P.M.Solozhenkin, S.R.Baratova, Innovations in mineral and coal processing . 1998

机译：银和金的生物溶剂：它们在胶体银和液态金的制备过程中的配合物
5. New chemistry with gold-nitrogen complexes: Synthesis and characterization of tetra-, tri-, and dinuclear gold(I) amidinate complexes, oxidative-addition to the dinuclear gold(I) amidinate. [D] . Abdou, Hanan Elsayed. 2006

机译：金-氮配合物的新化学方法：四核，三核和双核a金（I）配合物的合成与表征，,化双核金（I）的氧化加成反应。
6. Multi-functional bis(alkynyl)gold(iii) N⁁C complexes with distinct mechanochromic luminescence and electroluminescence properties [O] . Ben Yiu-Wing Wong, Hok-Lai Wong, Yi-Chun Wong, 2018

机译：具有明显的机械致变色发光和电致发光特性的多功能双（炔基）金（iii）N⁁C络合物
7. Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold(I) complexes featuring N-heterocyclic carbene and alkynyl ligands [O] . Samuel M. Meier-Menches, Brech Aikman, Daniel Döllerer, 2020

机译：对比较生物学评价和G-Quadreplex相互作用的两种有机金属金（I）复合物的互动研究，其具有N-杂环丁烯和炔基配体
8. An Electron Microscope Study of Quenched Gold-Palladium Alloys. I. A Study of the Electrical Resistivity Changes Produced by Quenching au Pd Alloys. II. The Effect of Quenched-in Vacancies on the Mechanical Properties of Gold-Palladium Alloys. III [R] . 1966

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Cobaltoceniumethynyl gold(I) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes

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