...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Agricultural and Food Chemistry >Hypoxia inducible factor pathways as targets for functional foods
【24h】

Hypoxia inducible factor pathways as targets for functional foods

机译：低氧诱导因子途径作为功能食品的目标

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The etiology of most chronic angiogenic diseases such as rheumatoid arthritis, atherosclerosis, diabetes complications, and cancer includes the presence of pockets of hypoxic cells growing behind aerobic cells and away from blood vessels. Hypoxic cells are the result of uncontrolled growth and insufficient vascularization and have undergone a shift from aerobic to anaerobic metabolism. Cells respond to hypoxia by stimulating the expression of hypoxia inducible factor (HIF), which is critical for survival under hypoxic conditions and in embryogenesis. HIF is a heterodimer consisting of the O-2-regulated subunit, HIF-1α, and the constitutively expressed aryl hydrocarbon receptor nuclear translocator, HIF-1β. Under hypoxic conditions, HIF-1α is stable, accumulates, and migrates to the nucleus where it binds to HIF-1β to form the complex (HIF-1α + HIF-1β). Transcription is initiated by the binding of the complex (HIF-1α + HIF-1β) to hypoxia responsive elements (HREs). The complex [(HIF-1α + HIF-1β) + HREs] stimulates the expression of genes involved in angiogenesis, anaerobic metabolism, vascular permeability, and inflammation. Experimental and clinical evidence show that these hypoxic cells are the most aggressive and difficult angiogenic disease cells to treat and are a major reason for antiangiogenic and conventional treatment failure. Hypoxia occurs in early stages of disease development (before metastasis), activates angiogenesis, and stimulates vascular remodeling. HIF-1α has also been identified under aerobic conditions in certain types of cancer. This review summarizes the role of hypoxia in some chronic degenerative angiogenic diseases and discusses potential functional foods to target the HIF-1α pathways under hypoxic and normoxic conditions. It is reported that dietary quinones, semiquinones, phenolics, vitamins, amino acids, isoprenoids, and vasoactive compounds can down-regulate the HIF-1 pathways and therefore the expression of several proangiogenic factors. Considering the lack of efficiency or the side effects of synthetic antiangiogenic drugs at clinical trials, down-regulation of hypoxia-induced angiogenesis by use of naturally occurring functional foods may provide an effective means of prevention.
机译：大多数慢性血管生成疾病的病因包括类风湿性关节炎，动脉粥样硬化，糖尿病并发症和癌症，其中包括在需氧细胞后面和远离血管生长的缺氧细胞袋的存在。缺氧细胞是不受控制的生长和不足的血管形成的结果，并且经历了从有氧代谢到无氧代谢的转变。细胞通过刺激缺氧诱导因子（HIF）的表达来应对缺氧，该因子对于在低氧条件下的存活和胚胎发生至关重要。 HIF是由O-2-调节的亚基HIF-1α和组成性表达的芳烃受体核转运子HIF-1β组成的异二聚体。在缺氧条件下，HIF-1α稳定，积累并迁移到细胞核，在此与HIF-1β结合形成复合物（HIF-1α+HIF-1β）。通过复合物（HIF-1α+HIF-1β）与缺氧反应元件（HRE）的结合来启动转录。复合物[（HIF-1α+HIF-1β）+ HREs]刺激涉及血管生成，无氧代谢，血管通透性和炎症的基因的表达。实验和临床证据表明，这些低氧细胞是最容易治疗和治疗的血管生成性疾病细胞，并且是抗血管生成和常规治疗失败的主要原因。缺氧发生在疾病发展的早期阶段（转移之前），激活血管生成并刺激血管重塑。在某些类型的癌症中，有氧条件下也已鉴定出HIF-1α。这篇综述总结了缺氧在某些慢性退行性血管生成疾病中的作用，并讨论了在缺氧和常氧条件下靶向HIF-1α途径的潜在功能性食品。据报道，饮食中的醌，半醌，酚类，维生素，氨基酸，类异戊二烯和血管活性化合物可以下调HIF-1途径，从而下调几种促血管生成因子的表达。考虑到在临床试验中缺乏合成抗血管生成药物的效率或副作用，通过使用天然存在的功能性食物来降低缺氧诱导的血管生成可能是一种有效的预防手段。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号