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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Anthocyanin metabolism in rats and their distribution to digestive area, kidney, and brain
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Anthocyanin metabolism in rats and their distribution to digestive area, kidney, and brain

机译：大鼠花色苷代谢及其在消化区，肾脏和大脑中的分布

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摘要

Anthocyanins are present in human diet due to their wide occurrence in fruits and beverages. They possess antioxidant activities and could be involved in several health effects. The aim of this study was to investigate anthocyanin metabolism and distribution in the digestive area organs (stomach, jejunum and liver) and kidney, as well as a target tissue (brain) in rats fed with a blackberry (Rubus fruticosus L.) anthocyanin-enriched diet for 15 days. Identification and quantification of anthocyanin metabolites was carried out by HPLC-ESI-MS-MS and HPLC-DAD, respectively. The stomach exhibited only native blackberry anthocyanins (cyanidin 3-O-glucoside and cyanidin 3-O-pentose), while in other organs (jejunum, liver, and kidney) native and methylated anthocyanins as well as conjugated anthocyanidins (cyanidin and peonidin monoglucuronides) were identified. Proportions of anthocyanin derivatives differed according to the organ considered, with the liver presenting the highest proportion of methylated forms. Jejunum and plasma also contained aglycone forms. In the brain, total anthocyanin content (blackberry anthocyanins and peonidin 3-O-glucoside) reached 0.25 ± 0.05 nmol/g of tissue (n = 6). The urinary excretion of total anthocyanins was low (0.19 ± 0.02% of the ingested amount). Thus, organs of the digestive area indicated a metabolic pathway of anthocyanins with enzymatic conversions (methylation and/or glucurono-conjugation). Moreover, following consumption of an anthocyanin- rich diet, anthocyanins enter the brain.
机译：花色苷由于在水果和饮料中的广泛存在而存在于人类饮食中。它们具有抗氧化活性，并可能涉及多种健康影响。这项研究的目的是研究饲喂黑莓（Rubus fruticosus L.）花青素的大鼠的消化区域器官（胃，空肠和肝脏），肾脏以及目标组织（大脑）中的花青素代谢和分布。丰富饮食15天。花色苷代谢物的鉴定和定量分别通过HPLC-ESI-MS-MS和HPLC-DAD进行。胃只表现出天然的黑莓花色苷（花青素3-O-葡糖苷和花青素3-O-戊糖），而在其他器官（空肠，肝脏和肾脏）中，天然的和甲基化的花青素以及共轭的花色苷（花青素和peonidin单葡糖醛酸苷）被确定。花青素衍生物的比例因所考虑的器官而异，其中肝脏占甲基化形式的比例最高。空肠和血浆也含有糖苷配基形式。在大脑中，总花色苷含量（黑莓花色苷和药苷3-O-葡萄糖苷）达到0.25＆PLUSMN; 0.05 nmol / g组织（n = 6）。总花青素的尿排泄量低（0.19＆PLUSMN;占摄入量的0.02％）。因此，消化区的器官表明花青素具有酶促转化（甲基化和/或葡萄糖醛酸结合）的代谢途径。此外，在食用富含花青素的饮食后，花青素进入大脑。

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