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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Investigation of the antioxidant activity of African potato (Hypoxis hemerocallidea).
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Investigation of the antioxidant activity of African potato (Hypoxis hemerocallidea).

机译：研究非洲马铃薯（Hypoxis hemerocallidea）的抗氧化活性。

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摘要

African potato (AP) is widely used as an immune booster for the treatment of various ailments. The norlignan glycoside hypoxoside, a major phytoconstituent of AP, its aglycon rooperol, and an aqueous preparation of lyophilized AP corms were screened for in vitro antioxidant activity using the DPPH (1,1-diphenyl-2-picryl hydrazine) and FRAP (ferric reducing ability of plasma) tests. Inhibition of quinolinic acid (QA) induced lipid peroxidation in rat liver tissue was studied in vitro using the thiobarbituric assay (TBA). Superoxide free radical scavenging activity was determined by the nitroblue tetrazolium assay. An isocratic HPLC method was developed to quantitatively determine both hypoxoside and rooperol concurrently. While rooperol and AP extracts reduced QA-induced lipid peroxidation in rat liver homogenates and significantly scavenged the superoxide anion at pharmacological doses, in comparison, hypoxoside was virtually devoid of activity. Since hypoxoside is converted to rooperol in vivo following administration of AP, the results indicate that the hypoxoside component in AP could have value as an antioxidant prodrug.
机译：非洲马铃薯（AP）被广泛用作治疗各种疾病的免疫增强剂。使用DPPH（1,1-二苯基-2-picryl肼）和FRAP（还原铁等离子体能力）测试。使用硫代巴比妥法（TBA）在体外研究了喹啉酸（QA）诱导的大鼠肝组织脂质过氧化的抑制作用。通过硝基蓝四唑鎓测定法测定超氧化物自由基清除活性。开发了等度HPLC方法，可同时定量测定次氧苷和rooperol。相比之下，rooperol和AP提取物可降低QA诱导的大鼠肝匀浆中脂质过氧化作用，并在药理剂量下显着清除超氧阴离子，而次氧苷几乎没有活性。由于在施用AP后，次生糖苷在体内转化为rooperol，结果表明，AP中的次生糖苷成分可能具有作为抗氧化剂前药的价值。

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