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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Profiling of Microbial-Derived Phenolic Metabolites in Human Feces after Moderate Red Wine Intake
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Profiling of Microbial-Derived Phenolic Metabolites in Human Feces after Moderate Red Wine Intake

机译：摄入适量红酒后人体粪便中微生物衍生的酚类代谢产物的分析

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摘要

A controlled and randomized trial study involving 41 healthy volunteers (33 intervention and 8 control subjects) was performed in order to establish changes in the microbial-derived phenolic metabolite profile of feces after moderate consumption of red wine (250 mL/day, 4 weeks). Out of the 35 phenolic metabolites identified, 10 compounds (mainly benzoic and 4-hydroxyvaleric acids) showed statistically significant increases (P < 0.05) after the wine intake. Also, the total phenolic metabolites content was significantly (P < 0.05) higher in the samples after the wine intake (625 ± 380 μg/g feces) in comparison to the samples before (358 ± 270μg/g feces), and a tentative distribution of the volunteers into three groups could be established: <500, 500-1000, and >1000 μg/g feces. These results suggest that a different gut microbial capacity to metabolize wine polyphenols exists among the human population, as observed for polyphenols from other sources.
机译：进行了一项包括41名健康志愿者（33名干预者和8名对照组）的随机对照研究，目的是确定适量饮用红酒（250 mL /天，4周）后粪便中微生物衍生的酚类代谢产物的变化。 。在摄入的酒中，鉴定出的35种酚类代谢物中，有10种化合物（主要是苯甲酸和4-羟基戊酸）显示出统计学上的显着增加（P <0.05）。此外，摄入酒后（625±380μg/ g粪便）的样品中的总酚类代谢物含量比之前（358±270μg/ g粪便）的样品高得多（P <0.05），并且暂定分布可以将志愿者分为三类：<500、500-1000和> 1000μg/ g粪便。这些结果表明，正如其他来源的多酚所观察到的那样，人群之间存在着不同的肠道微生物代谢葡萄酒中的多酚的能力。

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