MAP2c, but not tau, binds via its microtubule binding and bundles F-actin domain

Roger B; Al-Bassam J; Dehmelt L; Milligan RA; Halpain S

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MAP2c, but not tau, binds via its microtubule binding and bundles F-actin domain

机译：MAP2c通过其微管结合而不是tau结合并捆绑F-肌动蛋白域

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Background: MAP2 and tau are abundant microtubule-associated proteins (MAPs) in neurons. The development of neuronal dendrites and axons requires a dynamic interaction between microtubules and actin filaments. MAPs represent good candidates to mediate such interactions. Although MAP2c and tau have similar, well-characterized microtubule binding activities, their actin interaction is poorly understood.

机译：背景：MAP2和tau是神经元中大量的微管相关蛋白（MAPs）。神经元树突和轴突的发展需要微管和肌动蛋白丝之间的动态相互作用。 MAP代表了调解此类相互作用的良好候选者。尽管MAP2c和tau具有相似的，特征明确的微管结合活性，但对其肌动蛋白的相互作用了解甚少。

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《Current Biology: CB》 |2004年第5期|共9页
作者
Roger B; Al-Bassam J; Dehmelt L; Milligan RA; Halpain S;
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正文语种 eng
中图分类生物科学;
关键词
Protein 2c; Dynamic instability; Neurite initiation; Neuronal polarity; Dendritic spines; Filaments; Map-2; Cytoskeleton; Phosphorylation; Sequence;

机译：蛋白质2c;动态不稳定性;神经质引发;神经元极性;树突棘;细丝;Map-2;细胞骨架;磷酸化;序列;

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1. MAP2c, but not tau, binds via its microtubule binding and bundles F-actin domain [J] . Roger B, Al-Bassam J, Dehmelt L, Current Biology: CB . 2004,第5期

机译：MAP2c通过其微管结合而不是tau结合并捆绑F-肌动蛋白域
2. Quantitative mapping of microtubule-associated protein 2c (MAP2c) phosphorylation and regulatory protein 14-3-3ζ-binding sites reveals key differences between MAP2c and its homolog Tau. [J] . Séverine Jansen, Kate?ina Melková, Zuzana Tro?anová, The Journal of biological chemistry . 2017,第24期

机译：微管相关蛋白2c（MAP2c）磷酸化和调节蛋白14-3-3ζ结合位点的定量定位揭示了MAP2c及其同系物Tau之间的关键差异。
3. Quantitative mapping of microtubule-associated protein 2c (MAP2c) phosphorylation and regulatory protein 14-3-3ζ-binding sites reveals key differences between MAP2c and its homolog Tau [J] . Séverine Jansen, Kate?ina Melková, Zuzana Tro?anová, The Journal of biological chemistry . 2017,第16期

机译：微管相关蛋白2c（MAP2c）磷酸化和调节蛋白14-3-3ζ结合位点的定量作图揭示了MAP2c及其同系物Tau之间的关键差异
4. Detection of mutations in the binding domain of tau protein by kinesin-microtubule gliding assay [C] . Subramaniyan S.P., Tarhan M.C., Karsten S.L., IEEE International Conference on Micro Electro Mechanical Systems . 2014

机译：驱动蛋白-微管滑动实验检测tau蛋白结合域的突变
5. Exosomal proteome changes induced by human tau expression are modulated by the presence of the microtubule-binding domain and alternatively spliced exons 2-3 in SH-SY5Y neuroblastoma cells [D] . Aladwan, Mohammad Mahmoud. 2017

机译：SH-SY5Y神经母细胞瘤细胞中微管结合结构域的存在和其他剪接的外显子2-3的存在可以调节人tau表达诱导的外泌体蛋白质组变化
6. Quantitative mapping of microtubule-associated protein 2c (MAP2c) phosphorylation and regulatory protein 14-3-3ζ-binding sites reveals key differences between MAP2c and its homolog Tau [O] . Séverine Jansen, Kateřina Melková, Zuzana Trošanová, 2017

机译：微管相关蛋白2c（MAP2c）磷酸化和调节蛋白14-3-3ζ结合位点的定量作图揭示了MAP2c及其同系物Tau之间的关键差异
7. MAP2c, but Not Tau, Binds and Bundles F-Actin via Its Microtubule Binding Domain [O] . Roger Benoit, Al-Bassam Jawdat, Dehmelt Leif, 2004

机译：MAP2c，但不是Tau，通过其微管结合域将F-肌动蛋白结合并捆绑在一起

MAP2c, but not tau, binds via its microtubule binding and bundles F-actin domain

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