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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Intrinsically Water-Stable Keratin Nanopartides and Their in Vivo Biodistribution for Targeted Delivery
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Intrinsically Water-Stable Keratin Nanopartides and Their in Vivo Biodistribution for Targeted Delivery

机译：本质上水稳定的角蛋白纳米粒子及其靶向靶向的体内生物分布。

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摘要

Highly water-stable nanopartides of around 70 nm and capable of distributing with high uptake in certain organs of mice were developed from feather keratin. Nanopartides could provide novel veterinary diagnostics and therapeutics to boost efficiency in identification and treatment of livestock diseases to improve protein supply and ensure safety and quality of food. Nanopartides could penetrate easily into cells and small capillaries, surpass detection of the immune system, and reach targeted organs because of their nanoscale sizes. Proteins with positive and negative charges and hydrophobic domains enable loading of various types of drugs and, hence, are advantageous over synthetic polymers and carbohydrates for drug delivery. In this research, the highly cross-linked keratin was processed into nanopartides with diameters of 70 nm under mild conditions. Keratin nanopartides were found supportive to cell growth via an in vitro study and highly stable after stored in physiological environments for up to 7 days. At 4 days after injection, up to 18% of the cells in kidneys and 4% of the cells in liver of mice were penetrated by the keratin nanopartides.
机译：从羽毛角蛋白开发出了约70 nm的高水稳定性纳米粒子，并能够在小鼠的某些器官中高吸收分布。纳米颗粒可以提供新颖的兽医诊断和治疗方法，以提高识别和治疗牲畜疾病的效率，从而改善蛋白质供应并确保食品的安全性和质量。纳米粒子可以很容易地渗透到细胞和小毛细血管中，超过免疫系统的检测，并由于其纳米级尺寸而到达目标器官。具有正电荷和负电荷以及疏水结构域的蛋白质能够加载各种类型的药物，因此，在药物递送方面优于合成聚合物和碳水化合物。在这项研究中，高度交联的角蛋白在温和条件下被加工成直径为70 nm的纳米粒子。通过体外研究发现，角蛋白纳米粒子支持细胞生长，并且在生理环境中保存长达7天后具有高度稳定性。注射后第4天，角蛋白纳米粒子可穿透小鼠肾脏中18％的细胞和肝脏中4％的细胞。

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