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首页> 外文期刊>Journal of Agricultural and Food Chemistry >In Vitro Fermentation of Lactulose by Human Gut Bacteria
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In Vitro Fermentation of Lactulose by Human Gut Bacteria

机译：人类肠道细菌对乳果糖的体外发酵

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Lactulose has been known as a prebiotic that can selectively stimulate the growth of beneficial bifidobacteria and lactobacilli. Recent studies have indicated that Streptococcus rnutans, Clostridium perfringens, and Faecalihacterium prausnitzii are also able to utilize lactulose. However, the previous studies mainly focused on the utilization of lactulose by individual strains, and few studies were designed to identify the species that could utilize lactulose among gut microbiota. This study aimed to identify lactulose-metabolizing bacteria in the human gut, using in silico and traditional culture methods. The prediction results suggested that genes for the transporters and glycosidases of lactulose are well distributed in the genomes of 222 of 453 strains of gastrointestinal-tract bacteria. The screening assays identified 35 species with the ability to utilize lactulose, of which Cronobacter sakazakii, Enterococcus faecium, Klebsiella pneumoniae, and Pseudomonas putida were reported for the first time to be capable of utilizing lactulose. In addition, significant correlations between lactulose and galactooligosaccharide metabolism were found. Thus, more attention should be paid to bacteria besides bifidobacteria and lactobacilli to further investigate the relationship between functional oligosaccharides and gut bacteria.
机译：乳果糖是已知的益生元，可以选择性地刺激有益的双歧杆菌和乳杆菌的生长。最近的研究表明，核糖链球菌，产气荚膜梭状芽胞杆菌和法氏假单胞菌也能利用乳果糖。但是，以前的研究主要集中在个别菌株对乳果糖的利用上，很少有研究确定在肠道菌群中可以利用乳果糖的物种。这项研究旨在使用计算机模拟和传统培养方法鉴定人肠道中的乳果糖代谢细菌。预测结果表明，乳果糖的转运蛋白和糖苷酶基因在453个胃肠道细菌中的222个基因组中分布良好。筛选试验确定了35种具有利用乳果糖能力的物种，其中首次报道了阪崎肠杆菌，粪肠球菌，肺炎克雷伯菌和恶臭假单胞菌，其中第一种具有利用乳果糖的能力。此外，发现乳果糖和低聚半乳糖代谢之间存在显着相关性。因此，除了双歧杆菌和乳杆菌外，还应更多地关注细菌，以进一步研究功能性低聚糖与肠道细菌之间的关系。

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