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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Carnosic Acid as a Major Bioactive Component in Rosemary Extract Ameliorates High-Fat-Diet-Induced Obesity and Metabolic Syndrome in Mice
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Carnosic Acid as a Major Bioactive Component in Rosemary Extract Ameliorates High-Fat-Diet-Induced Obesity and Metabolic Syndrome in Mice

机译：肌酸作为迷迭香提取物中的主要生物活性成分改善小鼠的高脂饮食诱导的肥胖和代谢综合症

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In this study, we investigated the preventive effects of carnosic acid (CA) as a major bioactive component in rosemary extract (RE) on high-fat-diet-induced obesity and metabolic syndrome in mice. The mice were given a low-fat diet, a high-fat diet or a high-fat diet supplemented with either 0.14% or 0.28% (w/w) CA-enriched RE (containing 80% CA, REAM and RE#1H), or 0.5% (w/w) RE (containing 45% CA, RE#2), for a period of 16 weeks. There was the same CA content in the RE#1H and RE#2 diets and half of this amount in the RE#1L diet. The dietary RE supplementation significantly reduced body weight gain, percent of fat, plasma ALT, AST, glucose, insulin levels, liver weight, liver triglyceride, and free fatty acid levels in comparison with the mice fed with a HF diet without RE treatment. RE administration also decreased the levels of plasma and liver malondialdehyde, advanced glycation end products (AGEs), and the liver expression of receptor for AGE (RAGE) in comparison with those for mice of the HF group. Histological analyses of liver samples showed decreased lipid accumulation in hepatocytes in mice administrated with RE in comparison with that of HF-diet-fed mice. Meanwhile, RE administration enhanced fecal lipid excretion to inhibit lipid absorption and increased the liver GSH/GSSG ratio to perform antioxidant activity compared with HF group. Our results demonstrate that rosemary is a promising dietary agent to reduce the risk of obesity and metabolic syndrome.
机译：在这项研究中，我们调查了鼠尾草酸（CA）作为迷迭香提取物（RE）中的主要生物活性成分对小鼠高脂饮食诱发的肥胖和代谢综合征的预防作用。给予小鼠低脂饮食，高脂饮食或高脂饮食，添加0.14％或0.28％（w / w）的富含CA的RE（包含80％CA，REAM和RE＃1H）或0.5％（w / w）RE（包含45％CA，RE＃2），为期16周。 RE＃1H和RE＃2日粮中的CA含量相同，而RE＃1L日粮中CA含量的一半。与没有进行RE治疗的HF饮食喂养的小鼠相比，添加RE的饮食显着降低了体重增加，脂肪百分比，血浆ALT，AST，葡萄糖，胰岛素水平，肝脏重量，肝甘油三酯和游离脂肪酸水平。与HF组小鼠相比，RE给药还降低了血浆和肝脏丙二醛，晚期糖基化终产物（AGEs）的水平，以及AGE受体的肝表达（RAGE）。肝样品的组织学分析显示，与HF饮食喂养的小鼠相比，RE给予的小鼠肝细胞脂质蓄积减少。同时，与HF组相比，RE给药增强了粪便脂质排泄以抑制脂质吸收，并增加了肝脏GSH / GSSG的比值以执行抗氧化活性。我们的结果表明，迷迭香是减少肥胖和代谢综合征风险的有前途的饮食药物。

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