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首页> 外文期刊>Cryobiology: International Journal of Low Temperature Biology and Medicine >Influence of hydroxyapatite nanoparticles on the viscosity of dimethyl sulfoxide-H2O-NaCl and glycerol-H2O-NaCl ternary systems at subzero temperatures
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Influence of hydroxyapatite nanoparticles on the viscosity of dimethyl sulfoxide-H2O-NaCl and glycerol-H2O-NaCl ternary systems at subzero temperatures

机译：零以下温度下羟基磷灰石纳米粒子对二甲基亚砜-H2O-NaCl和甘油-H2O-NaCl三元体系粘度的影响

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摘要

The viscosity, at subzero temperatures, of ternary solutions commonly used in cryopreservation is tremendously important for understanding ice formation and molecular diffusion in biopreservation. However, this information is scarce in the literature. In addition, to the best of our knowledge, the effect of nanoparticles on the viscosity of these solutions has not previously been reported. The objectives of this study were thus: (i) to systematically measure the subzero viscosity of two such systems, dimethyl sulfoxide (Me2SO)-H2O-NaCl and glycerol-H2O-NaCl; (ii) to explore the effect of hydroxyapatite (HA) nanoparticles on the viscosity; and (iii) to provide models that precisely predict viscosity at multiple concentrations of cryoprotective agent (CPA) in saline solutions at subzero temperatures. Our experiments were performed in two parts. We first measured the viscosity at multiple CPA concentrations [0.3-0.75 (w/w)] in saline solution with and without nanoparticles at subzero temperatures (0 to -30 degrees C). The data exhibited a good fit to the Williams-Landel-Ferry (WLF) equation. We then measured the viscosity of residual unfrozen ternary solutions with and without nanoparticles during equilibrium freezing. HA nanoparticles made the solution more viscous, suggesting applications for these nanopartides in preventing cell dehydration, ice nucleation, and ice growth during freezing and thawing in cryopreservation. (C) 2014 Elsevier Inc. All rights reserved.
机译：低温保存中常用的三元溶液在零度以下的粘度对于理解生物保存中的冰形成和分子扩散极为重要。但是，该信息在文献中很少。此外，就我们所知，纳米颗粒对这些溶液粘度的影响以前尚未见报道。因此，本研究的目标是：（i）系统地测量两个这样的体系的零下粘度，即二甲亚砜（Me2SO）-H2O-NaCl和甘油-H2O-NaCl; （ii）探索羟基磷灰石（HA）纳米颗粒对粘度的影响; （iii）提供可精确预测零度以下温度下盐溶液中多种浓度的冷冻保护剂（CPA）粘度的模型。我们的实验分为两个部分。我们首先在零以下温度（0到-30摄氏度）下，在有和没有纳米颗粒的盐水溶液中，在多种CPA浓度[0.3-0.75（w / w）]下测量粘度。数据显示与Williams-Landel-Ferry（WLF）方程非常吻合。然后，我们在平衡冷冻过程中测量了有和没有纳米颗粒时残留的未冻结三元溶液的粘度。 HA纳米粒子使溶液更具粘性，表明这些纳米粒子在防止细胞脱水，冰核化和冷冻保存中的融化过程中的冰生长方面的应用。 （C）2014 Elsevier Inc.保留所有权利。

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