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首页> 外文期刊>Journal of Applied Polymer Science >Hydrogels of modified ethylenediaminetetraacetic dianhydride gelatin conjugated with poly(ethylene glycol) dialdehyde as a drug-release matrix
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Hydrogels of modified ethylenediaminetetraacetic dianhydride gelatin conjugated with poly(ethylene glycol) dialdehyde as a drug-release matrix

机译：修饰的乙二胺四乙酸二酐明胶与聚乙二醇二醛偶联作为药物释放基质的水凝胶

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摘要

Hydrogels have been recognized as versatile biomaterials in biomedical applications. This article describes the synthesis and characterization of a poly(ethylene glycol) (PEG) dialdehyde derivative, the modification of gelatin with ethylenediaminetetraacetic dianhydride (EDTAD), and the conjugation of PEG dialdehyde for enhanced hydrophilicity, biocompatibility, and flexibility. Hydrogels of gelatin conjugated with various percentages of PEG dialdehyde (10-30%), 35% EDTAD-modified gelatin, and 12% PEG dialdehyde conjugated with 31% EDTAD-modified gelatin with or without 1% chlorhexidine were prepared. For all the synthesized gel formulations, the swelling kinetics and drug release in pH 7.4 and pH 4.5 buffers at 37degreesC were studied. Gels of PEG-conjugated gelatin, 35% EDTAD-modified gelatin, and 12% PEG conjugated with 31% EDTAD-modified gelatin, with or without 1% chlorhexidine, showed significantly improved swelling ratios in comparison with gelatin. The drug release was unaffected by an increase in the percentage of PEG conjugation with gelatin. Complete drug release was recorded within 48 h in the pH 4.5 buffer, whereas in the pH 7.4 buffer, the drug release was accomplished within 128 h. (C) 2003 Wiley Periodicals, Inc. J Appl Polym Sci 91: 1059-1067, 2004. [References: 32]
机译：水凝胶已被认为是生物医学应用中的通用生物材料。本文介绍了聚乙二醇（PEG）二醛衍生物的合成与表征，明胶与乙二胺四乙酸二酐（EDTAD）的改性以及PEG二醛的共轭以增强亲水性，生物相容性和柔韧性。制备了与各种百分比的PEG二醛（10-30％），35％的EDTAD改性的明胶和12％的PEG二醛与31％的EDTAD改性的明胶结合的水凝胶，其中有或没有1％的洗必太。对于所有合成的凝胶制剂，研究了在37°C下在pH 7.4和pH 4.5缓冲液中的溶胀动力学和药物释放。与明胶相比，PEG缀合的明胶，35％EDTAD修饰的明胶和12％PEG与31％EDTAD修饰的明胶（含或不含1％洗必泰）的凝胶显示出明显改善的溶胀率。 PEG与明胶结合的百分比增加不会影响药物释放。在pH 4.5缓冲液中记录了48小时内药物的完全释放，而在pH 7.4缓冲液中记录了128小时内的药物释放。 （C）2003 Wiley Periodicals，Inc. J Appl Polym Sci 91：1059-1067，2004。[参考：32]

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