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首页> 外文期刊>Journal of Applied Polymer Science >Preparation and characterization of poly(L-lactide)/poly(epsilon-caprolactone) fibrous scaffolds for cartilage tissue engineering
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Preparation and characterization of poly(L-lactide)/poly(epsilon-caprolactone) fibrous scaffolds for cartilage tissue engineering

机译：软骨组织工程用聚（L-丙交酯）/聚（ε-己内酯）纤维支架的制备与表征

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摘要

Polyblend fibrous scaffolds in mass ratios of 100/0, 90/10, 80/20, and 70/30 from poly(L-lactide) (PLLA) and poly(E-caprolactone) (PCL) for cartilage tissue engineering were prepared in three steps: gelation, solvent exchanging, and freeze-drying. Effects of the blend ratio, the exchange medium, and the operating temperature on the morphology of scaffolds were investigated by SEM. PLLA/PCL scaffolds presented an ultrafine fibrous network with the addition of a "small block" structure. Smooth and regular fibrous networks were formed when ethanol was used as the exchange medium. Properties of the scaffolds, such as thermal and mechanical properties, were also studied. The results suggested that the compressive modulus declined as PCL amount increased. The incorporation of PCL effectively contributed to reduce the rigidity of PLLA. Bovine chondrocytes were seeded onto PLLA/PCL scaffold. Cells attached onto the fibrous network and their morphology was satisfactory. This polyblend fibrous scaffold will be a potential scaffold for cartilage tissue engineering. (C) 2003 Wiley Periodicals, Inc. [References: 25]
机译：制备用于软骨组织工程的聚（L-丙交酯）（PLLA）和聚（E-己内酯）（PCL）的质量比为100 / 0、90 / 10、80 / 20和70/30的Polyblend纤维支架。三个步骤：凝胶化，溶剂交换和冷冻干燥。通过SEM研究了共混比，交换介质和操作温度对支架形态的影响。 PLLA / PCL支架展示了一种超细纤维网络，并增加了“小方块”结构。当使用乙醇作为交换介质时，形成平滑且规则的纤维网络。还研究了支架的性质，例如热和机械性质。结果表明，压缩模量随PCL量的增加而下降。 PCL的合并有效地降低了PLLA的刚性。将牛软骨细胞接种到PLLA / PCL支架上。细胞附着在纤维网络上，其形态令人满意。这种混合纤维支架将是用于软骨组织工程的潜在支架。 （C）2003 Wiley Periodicals，Inc. [参考：25]

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