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首页> 外文期刊>Journal of Applied Polymer Science >Effect of a polymerizable cosurfactant on the microstructure and drug-release properties of nanoparticles synthesized through emulsion polymerization
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Effect of a polymerizable cosurfactant on the microstructure and drug-release properties of nanoparticles synthesized through emulsion polymerization

机译：可聚合助表面活性剂对乳液聚合合成纳米颗粒的微观结构和药物释放性能的影响

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摘要

The emulsion copolymerization of a partially water-soluble monomer, methyl methacrylate (MMA), and a water-soluble polymerizable cosurfactant, hydroxyethyl methacrylate (HEMA), was investigated. The microstructure of the copolymer varied as the HEMA concentration increased. The copolymer microstructure influenced drug entrapment and was studied with respect to the variation in the MMA/HEMA ratio, the crosslinker concentration, and the method of nanoparticle separation from the dispersion. The subsequent release of a lipophilic drug, carbamazepine, from nanoparticles was studied at three different copolymer compositions. (C) 2004 Wiley Periodicals, Inc. J. Appl Polym Sci 92: 402-409, 2004. [References: 17]
机译：研究了部分水溶性单体甲基丙烯酸甲酯（MMA）和水溶性可聚合表面活性剂甲基丙烯酸羟乙酯（HEMA）的乳液共聚。共聚物的微观结构随HEMA浓度的增加而变化。共聚物的微观结构影响了药物的截留，并针对MMA / HEMA比值，交联剂浓度以及从分散液中分离纳米颗粒的方法进行了研究。随后在三种不同的共聚物组成下研究了从纳米颗粒中释放出亲脂性药物卡马西平的方法。 （C）2004 Wiley Periodicals，Inc. J. Appl Polym Sci 92：402-409，2004。[参考：17]

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