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首页> 外文期刊>Journal of Applied Polymer Science >Rheological characterization of chitosan matrices: Influence of biopolymer concentration
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Rheological characterization of chitosan matrices: Influence of biopolymer concentration

机译：壳聚糖基质的流变特性：生物聚合物浓度的影响

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Viscoelastic properties of chitosan (CH), chitosan-poly(ethylene glycol) 400 (CH-PEG), and chitosanpoly(ethylene glycol) 400 with glyoxal as crosslinking agent (CH-PEG-Gly) systems were studied to analyze the effect of chitosan concentration (from 0.83 to 1.67%). Dynamic moduli increase as chitosan concentration increases for all systems. For CH and CH-PEG systems the loss modulus (G") is greater than the storage modulus (G') with predominance of the viscous over the elastic behavior. This corresponds to the characteristic behavior of solutions (nonstructured systems). The presence of PEG 400 induces a complementary reinforcement of the mechanical properties of the system. Except for the lowest chitosan concentration, when glyoxal was added to the CH-PEG systems, a gelled matrix was obtained. In this case, G' is greater than G", and practically independent of frequency. This behavior is typical of three-dimensional networks and indicates true gel formation, showing clear elastic behavior (tan delta < 1). In creep and recovery analysis, CH-PEG-Gly systems exhibited distinct regions that were mathematically modeled using Burger's model. This analysis shows that the CH-PEG-Gly matrices (from 1.25 to 1.67%) recover almost totally (100%). Therefore, these matrices could be useful as systems for the development of films for topical hydrophilic drug delivery, and the levels of the residual viscosity (eta(0)) or the complex viscosity (eta(*)) could be used to control drug release. (c) 2007 Wiley Periodicals, Inc.
机译：研究了以乙二醛为交联剂（CH-PEG-Gly）的壳聚糖（CH），壳聚糖-聚乙二醇400（CH-PEG）和壳聚糖-聚乙二醇400的粘弹性，以分析壳聚糖的作用浓度（从0.83到1.67％）。对于所有系统，随着壳聚糖浓度的增加，动态模量也会增加。对于CH和CH-PEG系统，其损耗模量（G“）大于储能模量（G'），其中粘滞性超过弹性行为。这对应于溶液（非结构化系统）的特征行为。 PEG 400可以增强系统的机械性能。除最低的壳聚糖浓度外，将乙二醛添加到CH-PEG系统中可获得凝胶状基质。在这种情况下，G'大于G“，并且实际上与频率无关。此行为是三维网络的典型行为，表明真正的凝胶形成，显示出清晰的弹性行为（tan delta <1）。在蠕变和回复分析中，CH-PEG-Gly系统表现出不同的区域，这些区域使用Burger's模型进行了数学建模。该分析表明，CH-PEG-Gly基质（从1.25到1.67％）几乎完全恢复（100％）。因此，这些基质可以用作开发用于局部亲水性药物递送的薄膜的系统，并且可以使用残留粘度（eta（0））或复数粘度（eta（*））的水平来控制药物释放。 （c）2007年Wiley Periodicals，Inc.

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