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首页> 外文期刊>Journal of Applied Polymer Science >Gelatin multilayers assembled on poly(L-lactic acid) surface for better cytocompatibility
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Gelatin multilayers assembled on poly(L-lactic acid) surface for better cytocompatibility

机译：明胶多层组装在聚（L-乳酸）表面，具有更好的细胞相容性

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Gelatin multilayers were assembled on PLLA substrate at pH 3, 5, and 7, which was below, around, and above the isoelectric point of the amphoteric polymer, using the layer-by-layer assembly technique. The multilayer deposition on the PLLA substrate was monitored by X-ray photoelectron spectroscopy (XPS) and water contact angle measurement. The XPS, water contact angle, and atomic force microscopy data indicated that the layer thickness, surface hydrophicity, and surface morphology of the gelatin multilayers assembled strongly depended on the pH at which the layers were deposited. Chondrocyte culture was used to test the cell attachment, cell morphology, and cell viability on the PLLAs modified with gelatin multilayers. All these modified PLLAs exhibited dramatically improved cytocompatibility compared with the virgin PLLA, and even better performance than that of tissue culture polystyrene (TCPS). The best cell compatibility was observed for the gelatin multilayers assembled at pH = 5. These results indicate that the cell compatibility of biodegradable polyesters can be effectively and facilely improved by assembly of gelatin multilayers, and the performance can be controlled by adjusting the solution pH at which the multilayers are deposited. This may help the design and fabrication of better scaffolds for tissue engineering. (c) 2008 Wiley Periodicals, Inc.
机译：使用逐层组装技术，将明胶多层膜组装在pH 3、5和7的PLLA基材上，该pH低于，周围和高于两性聚合物的等电点。通过X射线光电子能谱（XPS）和水接触角测量来监测PLLA衬底上的多层沉积。 XPS，水接触角和原子力显微镜数据表明，组装的明胶多层的层厚度，表面亲水性和表面形态在很大程度上取决于沉积这些层的pH。软骨细胞培养用于测试用明胶多层修饰的PLLA上的细胞附着，细胞形态和细胞活力。与原始PLLA相比，所有这些修饰的PLLA均显示出显着改善的细胞相容性，甚至比组织培养聚苯乙烯（TCPS）的性能更好。对于在pH = 5时组装的明胶多层膜，观察到最佳的细胞相容性。这些结果表明，通过组装明胶多层膜，可以有效而轻松地改善可生物降解聚酯的细胞相容性，并且可以通过调节溶液的pH值来控制性能。沉积多层。这可以帮助设计和制造用于组织工程的更好的支架。 （c）2008 Wiley期刊公司

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