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首页> 外文期刊>Journal of Applied Polymer Science >Cytotoxicity and Hemocompatibility of a Family of Novel MeO-PEG-Poly (D,L-Lactic-co-glycolic acid)-PEG-OMe Triblock Copolymer Nanoparticles
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Cytotoxicity and Hemocompatibility of a Family of Novel MeO-PEG-Poly (D,L-Lactic-co-glycolic acid)-PEG-OMe Triblock Copolymer Nanoparticles

机译：新型MeO-PEG-聚（D，L-乳酸-乙醇酸）-PEG-OMe三嵌段共聚物纳米粒子家族的细胞毒性和血液相容性

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摘要

A family of newly synthesized monomethoxy (polyethylene glycol)-poly (D,L-lactic glycolic acid)monomethoxy(polyethylene glycol) (MeO-PEG-poly (D,L-lactic-co-glycolic acid)-PEG-OMe, PELGE) biodegradable polymers are candidates for intravenous nanoparticle drug, because of their merits of biocompatibility and blood compatibility, and their capability of escaping from the endothelium system (RES) and adsorbing proteins. In the current research, relationships between composition, cytotoxicity, and hemocompatibility of a series of blank PELGE nanoparticles were investigated. Cytotoxicity on Chang cell lines was investigated using the methyl thiazolyl tetrazolium (MTT) assay. Human and rabbit blood were used in studies of red blood cell hemolysis, whole blood clotting time, plasma recalcification profiles, and red blood cell form and appearance in whole blood. The results that the molecular weight of PEG used in the synthesis of polymers influenced their characteristics. Generally, as the molecular weight of PEG increased, increased cytotoxicity and hemocompatibility were observed. The RGR (relative growth rate) of PELGE nanoparticles synthesized with PEG 550 was above 70%, while that of PELGE nanoparticles synthesized with PEG 750 and PEG 2000 was in the range of 55-105% and 36-87%, respectively. For PELGE nanoparticles synthesized with PEG 550, most hemolysis values were in the range of 13%, while for PELGE nanoparticles synthesized with PEG 750 and PEG 2000 hemolysis values were 1-2%, and below 2%, respectively. None of the nanoparticles Caused changes in red blood cell form or appearance. Based on the results, 12 kinds of PELGE were chosen for further studies.
机译：新合成的单甲氧基（聚乙二醇）-聚（D，L-乳酸乙醇酸）单甲氧基（聚乙二醇）（MeO-PEG-聚（D，L-乳酸-乙醇酸）-PEG-OMe，PELGE可生物降解的聚合物因其生物相容性和血液相容性的优点，以及它们从内皮系统（RES）逃逸和吸附蛋白的能力而成为静脉内纳米药物的候选者。在当前的研究中，研究了一系列空白PELGE纳米颗粒的组成，细胞毒性和血液相容性之间的关系。使用甲基噻唑基四唑（MTT）测定法研究了Chang细胞系的细胞毒性。人血和兔血用于研究红细胞溶血，全血凝固时间，血浆再钙化曲线以及全血中红细胞的形态和外观。结果表明，用于聚合物合成的PEG分子量影响其特性。通常，随着PEG分子量的增加，观察到细胞毒性和血液相容性增加。用PEG 550合成的PELGE纳米颗粒的RGR（相对生长率）高于70％，而用PEG 750和PEG 2000合成的PELGE纳米颗粒的RGR分别在55-105％和36-87％的范围内。对于用PEG 550合成的PELGE纳米颗粒，大多数溶血值在13％的范围内，而对于用PEG 750和PEG 2000合成的PELGE纳米颗粒，溶血值分别为1-2％和低于2％。纳米颗粒均未引起红细胞形式或外观改变。根据结果​​，选择了12种PELGE进行进一步研究。

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