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首页> 外文期刊>Journal of Applied Polymer Science >Thermosensitive Nanoparticles Prepared from Poly(N-isopropylacrylamide-acrylamide-vinilpyrrolidone) and its Blend with Poly(lactide-co-glycolide) for Efficient Drug Delivery System
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Thermosensitive Nanoparticles Prepared from Poly(N-isopropylacrylamide-acrylamide-vinilpyrrolidone) and its Blend with Poly(lactide-co-glycolide) for Efficient Drug Delivery System

机译：聚（N-异丙基丙烯酰胺-丙烯酰胺-乙烯基吡咯烷酮）及其与聚丙交酯-乙交酯的共混物制备的热敏纳米颗粒，用于高效药物递送系统

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摘要

Temperature-responsive polymers have become increasingly attractive as carrier for the injectable drug delivery systems. In the present work, we have studied the preparation of poly(N-isopropylacrylamide-acrylamide-vinilpyrrolidone) (NIPAAm-AAm-VP terpolymer) nanoparticulated terpolymer and its blend with poly(lactide-co-glycolide, PLGA,; molar ratio of lactide/glycolid 1/3). Thermosensitive terpolymer, poly(NIPAAM-AAm-VP) was prepared by free-radical polymerization aqueous solution. The natioparticles of poly(NIPAAm-AAm-VP) and its blend with PLGA containing naltrexone were prepared using the evaporation and w/o emulsion-solvent evaporation methods, respectively. Narloparticles prepared from terpolymer-PLGA blend at low polymer concentration (5%) shows larger particle size (>300 nm) and higher drug content%. Various types of nanoparticles showed a burst release of less than 10%, after 24 h. The results suggest that by regulating different variables, desired release profiles of naltrexone can be achieved using a blend of PLGS-ploy(NIPAAm-AAm-VP) nano-particulate system. (c) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 111: 1905-1910, 2009
机译：温度响应性聚合物作为可注射药物递送系统的载体变得越来越有吸引力。在本工作中，我们研究了聚（N-异丙基丙烯酰胺-丙烯酰胺-乙烯基吡咯烷酮）（NIPAAm-AAm-VP三元共聚物）纳米颗粒三元共聚物的制备及其与聚丙交酯-乙交酯乙交酯（PLGA）的共混物;丙交酯的摩尔比/糖脂1/3）。通过自由基聚合水溶液制备热敏性三元共聚物聚（NIPAAM-AAm-VP）。分别使用蒸发法和不使用乳液溶剂蒸发法制备了聚（NIPAAm-AAm-VP）纳米粒子及其与含纳曲酮的PLGA的共混物。由低聚物浓度（5％）的三元共聚物-PLGA共混物制备的纳洛颗粒显示出较大的粒径（> 300 nm）和较高的药物含量％。 24小时后，各种类型的纳米粒子显示出小于10％的爆发释放。结果表明，通过调节不同的变量，可以使用PLGS-ploy（NIPAAm-AAm-VP）纳米颗粒的混合物实现纳曲酮的所需释放曲线。 （c）2008 Wiley Periodicals，Inc. J Appl Polym Sci 111：1905-1910，2009

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