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首页> 外文期刊>Journal of Applied Polymer Science >Control of Release Characteristics in pH-Sensitive Poly(vinyl alcohol)/Poly(acrylic acid) Microcapsules Containing Chemically Treated Alumina Core
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Control of Release Characteristics in pH-Sensitive Poly(vinyl alcohol)/Poly(acrylic acid) Microcapsules Containing Chemically Treated Alumina Core

机译：含化学处理氧化铝核的pH敏感的聚乙烯醇/聚丙烯酸丙烯酸微囊的释放特性控制

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摘要

The pH-sensitive poly(vinyl alcohol)/poly (acrylic acid) hydrogel microcapsules containing vitamin B-12-loaded Al2O3 core were prepared with a three-step emulsion polymerization. Al2O3 was chemically treated with HCl or NaOH solutions at room temperature for 24 h to modify the binding properties with vitamin B-12. The colon-targeted release characteristics of vitamin B-12 from the microcapsules were evaluated at different pHs. These microcapsules showed the faster and larger release of vitamin B-12 due to the high swelling of microcapsule shell as the pH was changed into more basic condition. However, these microcapsules showed the slower and less release of vitamin B-12 as the acid value of Al2O3 increased due to the strong binding interaction between Al2O3 core and vitamin B-12 even though the initial loading of vitamin B-12 was higher.
机译：通过三步乳液聚合反应制备了含维生素B-12的Al2O3核的pH敏感的聚乙烯醇/聚丙烯酸水凝胶微胶囊。 Al2O3在室温下用HCl或NaOH溶液化学处理了24小时，以改变与维生素B-12的结合性能。在不同的pH值下，评估了维生素B-12从微胶囊的结肠靶向释放特性。这些微胶囊显示出维生素B-12更快，更大的释放，这是由于随着pH值改变为更碱性，微胶囊壳的高度溶胀。但是，这些微胶囊显示出维生素B-12的释放缓慢且较少，这是由于Al2O3核心与维生素B-12之间的强结合相互作用导致Al2O3的酸值增加，即使维生素B-12的初始负载较高。

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