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首页> 外文期刊>Journal of Applied Polymer Science >Reduction of Postsurgical Adhesion Formation with CM-Chitosan Hydrogel Barriers Prepared by Using gamma-Irradiation
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Reduction of Postsurgical Adhesion Formation with CM-Chitosan Hydrogel Barriers Prepared by Using gamma-Irradiation

机译：γ射线制备的CM-壳聚糖水凝胶阻滞剂减少术后粘连形成

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摘要

To evaluate the efficiency of carboxymethylchitosan (CM-chitosan)-based hydrogels as barriers for reducing postsurgical adhesions, CM-chitosan was synthesized to simplify the hydrogel-making process, and the CM-chitosan solutions were cross-linked by using gamma-ray irradiation to create the desired hydrogels instead of using chemical cross-linking reagents. The prepared CM-chitosan hydrogels were characterized by a FTIR spectroscopy, swelling behavior, gel-fraction content,and mechanical property such as gel strength of a hydrogel and the results showed a good swelling behavior and mechanical properties. Also, the radiation-induced CM-chitosan hydrogels significantly reduced and inhibited the postsurgical adhesions in the rat models.
机译：为了评估基于羧甲基壳聚糖（CM-壳聚糖）的水凝胶作为减少术后粘连的屏障的效率，合成了CM-壳聚糖以简化水凝胶的制备过程，并使用伽马射线辐照使CM-壳聚糖溶液交联。生成所需的水凝胶，而不使用化学交联剂。制备的CM-壳聚糖水凝胶通过FTIR光谱，溶胀行为，凝胶分数含量以及水凝胶的凝胶强度等机械性能进行了表征，结果显示良好的溶胀性能和机械性能。同样，在大鼠模型中，辐射诱导的CM-壳聚糖水凝胶显着减少并抑制了术后粘连。

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