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首页> 外文期刊>Journal of Applied Polymer Science >Influence of the polymer structure on the drug-polymer interactions in the micellar nanoparticles: Mixed homopolymer and copolymerized cores
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Influence of the polymer structure on the drug-polymer interactions in the micellar nanoparticles: Mixed homopolymer and copolymerized cores

机译：胶束纳米颗粒中聚合物结构对药物-聚合物相互作用的影响：混合均聚物和共聚核

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摘要

The two strategies of mixing and copolymerizing were used to incorporate more drug-compatible butylene adipate (BA) repeating units into the less drug-compatible unsaturated poly(cis-2-butene adipate) (PCBA) core of micelles. Novel parameters were defined on the basis of the hydrodynamic radius of the particles. A comparison of the encapsulation capabilities of the different copolymerized and mixed micelles was performed with these parameters. Both the mixed and core-copolymerized micelles were indicated to have spherical morphologies and synergic properties of the copolymerized and mixed repeating units. They exhibited a higher encapsulation of the drug, a lower critical micelle concentration, and more controlled release behavior compared to the pure PCBA micelles. In addition, a comparative study of the two strategies was performed in the presence of same molar ratios of BA in the core. The mixed micelle formulation was found to be more effective in making a core more compatible to quercetin (as a model anticancer hydrophobic drug) with better pharmaceutical properties.
机译：混合和共聚这两种策略被用来将更多药物相容性的己二酸丁二酯（BA）重复单元并入药物相容性更差的不饱和聚（顺式-2-丁烯己二酸）（PCBA）核中。基于颗粒的流体动力学半径定义了新的参数。使用这些参数比较了不同的共聚和混合胶束的包封能力。混合和核心共聚的胶束均具有球形形态和共聚和混合重复单元的协同性能。与纯PCBA胶束相比，它们表现出更高的药物封装度，更低的临界胶束浓度和更受控的释放行为。另外，在芯中存在相同摩尔比的BA的情况下，对两种策略进行了比较研究。发现混合的胶束制剂在使核心与槲皮素（作为抗癌疏水性模型药物）更相容方面更有效，具有更好的药物特性。

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