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Method for preparing polymeric nanoparticles, Method for preparing a micellar cup, Reconstitutable polymer micelles, Bioactive polymeric nanoparticle composition, Method for providing a patient a medicament and Method for preparing polymeric nanoparticle compositions
Method for preparing polymeric nanoparticles, Method for preparing a micellar cup, Reconstitutable polymer micelles, Bioactive polymeric nanoparticle composition, Method for providing a patient a medicament and Method for preparing polymeric nanoparticle compositions
METHOD FOR PREPARING POLYMERIC NANOParticles, METHOD FOR PREPARING A MICELAR COMPOSITION, RECONTITUBLE POLYMERIC COMPOSITION, BIOACTIVE POLYMERIC COMPANIES OF NARROPARTIC PROPIRCULAR PROCEDURES The invention relates to polymeric nanoparticles having a hydrophobic core and the hydrophilic shell is formed from: 1) N-isopropyl acrylamide (NIPAAM) at a molar ratio of about 50% to about 90%, and preferably 60%. for specific shipping routes such as oral or parenteral; or water-soluble vinyl derivatives such as vinylpyrolidone (VP) or vinyl acetate (VA), or water-insoluble vinyl derivatives such as methyl methacrylate (MMA) or styrene (ST) at a molar ratio of about 10%. about 30%, and acrylic acid (AA) at a molar ratio of about 10% to about 30%. The nanoparticles formed may optionally be surface functional using reactive groups present in AA, including PEGylation, or conjugation of fractions such as chemotherapeutic contrast agents, antibodies, radionuclides, ligands, and sugars, for diagnostic, therapeutic, and imaging purposes. The polymeric nanoparticles are preferably dispersed in aqueous solutions. The polymeric nanoparticles incorporates one or more types of drugs or bioactive agents into the hydrophobic nucleus; where necessary, the medicament or bioactive agent may be conjugated to the nanoparticle surface by functional reactive groups. The polymeric nanoparticles are capable of delivering said medicaments or bioactive agents by oral, parenteral, or topical route. Polymeric nanoparticles allow poorly water-soluble drugs or bioactive agents, or those with poor oral bioavailability, to be formulated in an aqueous solution, and allow their convenient delivery into the systemic circulation.
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