• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Applied Polymer Science >Preparation and Characterization of 2-Methacryloyloxyethyl Phosphorylcholine Polymer Nanofibers Prepared via Electrospinning for Biomedical Materials
【24h】

Preparation and Characterization of 2-Methacryloyloxyethyl Phosphorylcholine Polymer Nanofibers Prepared via Electrospinning for Biomedical Materials

机译：生物医学材料静电纺丝制备2-甲基丙烯酰氧基乙基磷酸胆碱聚合物纳米纤维及其表征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Electrospun nanofibers of poly (2-methacryloyloxyethyl phosphorylcholine) (MPC) possessing excellent hemocompatibility were successfully fabricated first. These nanofibers were investigated as drug-delivery vehicles for suppressing the acute thrombogenicity of vascular grafts to lower the risk of coronary artery disease by improving the graft patency rate; the graft patency rate is the percentage of patients who do not have any blockage in a graft after a stent-graft treatment. We varied the MPC concentrations in ethanol from 1 to 10 wt % to fabricate electrospun MPC fibers. Scanning electron microscopy images revealed that when the MPC concentration was lower than 5 wt %, beads instead of fibers were formed. When the MPC concentration was increased (>5 wt %), uniform fibers were produced with average fiber diameters of about 160 nm (5 wt %), 640 nm (7.5 wt %), and 1270 nm (10 wt %). In vitro drug-release tests showed that a higher amount of drugs was diffused from MPC fibers with small diameters; this indicated a faster drug-release rate for the thinner MPC fibers. Diameter-controlled MPC fibers could be used as a new vascular graft materials.
机译：首先成功地制备了具有优异血液相容性的聚（2-甲基丙烯酰氧基乙基磷酰胆碱）（MPC）电纺纳米纤维。研究了这些纳米纤维作为药物输送工具，通过提高移植物通畅率来抑制血管移植物的急性血栓形成，从而降低了冠心病的风险。移植物通畅率是指在支架植入物治疗后没有任何阻塞的患者百分比。我们将乙醇中的MPC浓度从1 wt％更改为10 wt％，以制造电纺MPC纤维。扫描电子显微镜图像显示，当MPC浓度低于5wt％时，形成珠而不是纤维。当MPC浓度增加（＞ 5wt％）时，产生具有平均纤维直径为约160nm（5wt％），640nm（7.5wt％）和1270nm（10wt％）的均匀纤维。体外药物释放试验表明，从直径较小的MPC纤维中扩散了更多的药物;这表明较细的MPC纤维的释药速度更快。直径控制的MPC纤维可用作新型的血管移植材料。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号