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首页> 外文期刊>Journal of Applied Polymer Science >Modification of Ibuprofen Drug Release from Poly(ethylene glycol) Layered Silicate Nanocomposites Prepared by Hot-Melt Extrusion
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Modification of Ibuprofen Drug Release from Poly(ethylene glycol) Layered Silicate Nanocomposites Prepared by Hot-Melt Extrusion

机译：热熔挤出制备的聚（乙二醇）层状硅酸盐纳米复合材料中布洛芬药物释放的改性

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摘要

Composites of the poorly water soluble drug ibuprofen, a nonsteroidal anti-inflammatory commonly used for pain relief, with layered silicates (nanoclays) and a poly(ethylene glycol) (PEG) were prepared by hot melt extrusion. A highly intercalated and partially exfoliated morphology was determined using wide-angle x-ray diffraction, field emission scanning electron microscopy, and high-resolution transmission electron microscopy. The crystalline content of PEG was significantly reduced, as shown by differential scanning calorimetry studies, as a consequence of the large surface area of clay platelets physically hindering polymer chain dynamics and, in the case of montmorillonite, by tethering of PEG via hydrogen bonding. Addition of layered silicate retarded the release of ibuprofen from the PEG matrix, even though the crystalline content of PEG was reduced. This study therefore indicates that drug release in solid dispersion systems may be modified or indeed tailored by the inclusion of layered silicates.
机译：通过热熔挤出制备水溶性差的药物布洛芬（一种通常用于缓解疼痛的非甾体类抗炎药）与层状硅酸盐（纳米粘土）和聚乙二醇（PEG）的复合材料。使用广角x射线衍射，场发射扫描电子显微镜和高分辨率透射电子显微镜确定高度嵌入和部分剥落的形态。差示扫描量热法研究表明，PEG的结晶含量显着降低，这是由于粘土薄片的大表面积物理上阻碍了聚合物链的动力学，对于蒙脱土而言，是通过氢键对PEG进行束缚。即使降低了PEG的结晶含量，层状硅酸盐的添加也阻碍了布洛芬从PEG基质的释放。因此，这项研究表明，固体分散体系中的药物释放可能会通过加入层状硅酸盐而得到改善或确实得到调整。

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