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首页> 外文期刊>Journal of Applied Polymer Science >Preparation and Application in Drug Controlled Delivery of pH-Sensitive P(CE-co-DMAEMA-co-MEG) Hydrogel
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Preparation and Application in Drug Controlled Delivery of pH-Sensitive P(CE-co-DMAEMA-co-MEG) Hydrogel

机译：pH敏感的P（CE-co-DMAEMA-co-MEG）水凝胶的制备及其在药物控释中的应用

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摘要

A pH-sensitive hydrogel [P(CE-co-DMAEMA-co-MEG)] was synthesized by the free-radical crosslinking polymerization of N,N-dimethylaminoethyl methacrylate (DMAEMA), poly(ethylene glycol) methyl ether methacrylate(MPEG-Mac) and methoxyl poly(ethylene glycol)-poly(caprolactone)-methacryloyl methchloride (PCE-Mac). The effects of pH and monomer content on swelling property, swelling and deswelling kinetics of the hydrogels were examined and hydrogel microstructures were investigated by SEM. Sodium salicylate was chosen as a model drug and the controlled-release properties of hydrogels were pilot studied. The results indicated that the swelling ratios of the gels in stimulated gastric fluids (SGF, pH = 1.4) were higher than those in stimulated intestinal fluids (SIF, pH = 7.4), and followed a non-Fickian and a Fickian diffusion mechanism, respectively. In vitro release studies showed that its release rate depends on different swelling of the network as a function of the environmental pH and DMAEMA content. SEM micrographs showed homogenous pore structure of the hydrogel with open pores at pH 1.4.
机译：pH敏感水凝胶[P（CE-co-DMAEMA-co-MEG）]是通过N，N-甲基丙烯酸N，N-二甲基氨基乙酯（DMAEMA），聚乙二醇甲基丙烯酸甲醚（MPEG- Mac）和甲氧基聚（乙二醇）-聚（己内酯）-甲基丙烯酰甲基氯（PCE-Mac）。研究了pH和单体含量对水凝胶溶胀性能，溶胀和溶胀动力学的影响，并通过SEM研究了水凝胶的微观结构。选择水杨酸钠作为模型药物，并初步研究了水凝胶的控释特性。结果表明，刺激的胃液（SGF，pH = 1.4）中凝胶的溶胀率高于刺激的肠液（SIF，pH = 7.4）中的凝胶溶胀率，并且分别遵循非Fickian和Fickian扩散机制。 。体外释放研究表明，其释放速率取决于网络pH的不同溶胀度，这取决于环境pH和DMAEMA含量。 SEM显微照片显示在pH 1.4下具有开孔的水凝胶的均匀孔结构。

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