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首页> 外文期刊>Journal of Applied Polymer Science >Zein-Based Micro- and Nano-Particles for Drug and Nutrient Delivery: A Review
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Zein-Based Micro- and Nano-Particles for Drug and Nutrient Delivery: A Review

机译：基于玉米醇溶蛋白的微颗粒和纳米颗粒用于药物和营养的输送：综述

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摘要

Zein is the major storage protein from corn with strong hydrophobicity and unique solubility and has been considered as a versatile food biopolymer. Due to the special tertiary structures, zein can self-assemble to form micro- and nano-particles through liquid–liquid dispersion or solvent evaporation approaches. Zein-based delivery systems have been particularly investigated for hydrophobic drugs and nutrients. Recently, increasing attention has been drawn to fabricate zein-based advanced drug delivery systems for various applications. In this review, the molecular models of zein tertiary structure and possible mechanisms involved in zein selfassembly micro- and nano-particles are briefly introduced. Then, a state-of-the-art introduction and discussion are given in terms of preparation, characterization, and application of zein-based particles as delivery systems in the fields of food science, pharmaceutics, and biomedicine.
机译：玉米蛋白是玉米的主要储藏蛋白，具有很强的疏水性和独特的溶解性，被认为是一种多功能的食品生物聚合物。由于特殊的三级结构，玉米醇溶蛋白可以通过液-液分散或溶剂蒸发方法自组装形成微米和纳米颗粒。基于玉米蛋白的递送系统已针对疏水性药物和营养物质进行了专门研究。近来，人们越来越关注制造用于各种应用的基于玉米醇溶蛋白的先进药物递送系统。在这篇综述中，简要介绍了玉米醇溶蛋白三级结构的分子模型以及涉及玉米醇溶蛋白自组装微粒和纳米颗粒的可能机理。然后，就玉米醇溶蛋白基颗粒作为食品科学，制药和生物医学领域中的递送系统的制备，表征和应用进行了最新的介绍和讨论。

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