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首页> 外文期刊>Journal of Applied Polymer Science >Design and in vivo assessment of polyester copolymers based on trimethylene carbonate and epsilon-caprolactone
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Design and in vivo assessment of polyester copolymers based on trimethylene carbonate and epsilon-caprolactone

机译：基于碳酸亚丙酯和ε-己内酯的聚酯共聚物的设计和体内评估

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摘要

Poly(trimethylene carbonate-co-caprolactone) (PTCL) copolymers with various trimethylene carbonate ratios were synthesized by ring-opening polymerization and were used to prepare implants for an in vivo experiment. Medical silicone rubber was used as the control. Implants were prepared by compression molding with a laboratory instrument. The properties of these copolymer implants were investigated. PTCL implants and silicone rubbers were implanted subcutaneously in the dorsal region of New Zealand white rabbits. The assessment was performed 1, 2, 3, 4, 5, 6, 7, and 8 months postoperatively by the determination of the weight loss, water uptake, thermal behavior, molecular weight of the explanted implants, and histological examination. During the 8-month implantation, the value of maximum weight loss was found to be 25%. A continuous decrease in the molecular weight occurred. No remarkable tissue reactions were observed during degradation, and foreign-body reactions were similar to those of silicone rubbers, which are commercially available materials. In this study, we aimed to indicate the likely clinical behavior but good biodegradable properties of PTCL copolymers compared to those of silicone rubber. This may open a new avenue of application for them in the drug industry. (C) 2015 Wiley Periodicals, Inc.
机译：通过开环聚合反应合成了具有各种碳酸三亚甲基酯比例的聚碳酸三亚甲基-共己内酯（PTCL）共聚物，并用于制备用于体内实验的植入物。医用硅橡胶用作对照。植入物通过用实验室仪器压模来制备。研究了这些共聚物植入物的性能。 PTCL植入物和硅橡胶被皮下植入新西兰白兔的背部区域。术后1、2、3、4、5、6、7和8个月进行评估，方法是确定体重减轻，吸水率，热行为，外植体分子量和组织学检查。在8个月的植入过程中，发现最大重量减轻值为25％。分子量连续降低。在降解过程中没有观察到明显的组织反应，并且异物反应类似于硅橡胶，后者是可商购的材料。在这项研究中，我们旨在说明与硅橡胶相比，PTCL共聚物可能具有的临床行为，但具有良好的生物降解性能。这可能为他们在制药行业中的应用开辟新的途径。 （C）2015年Wiley Periodicals，Inc.

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