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Critical update on 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer science

机译:关于2-甲基丙烯酰氧基乙基磷酰胆碱(MPC)聚合物科学的重要更新

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摘要

2-Methacryloyloxyethyl phosphorylcholine (MPC) is a custom methacrylate with a zwitterionic phosphorylcholine moiety on the side chain. In the past 25 years, MPC has been used as a building block for a wide range of polymeric biomaterials because of its excellent resistance to nonspecific protein adsorption, cell adhesion, and blood coagulation. Recently, MPC polymers with specific features have been used in bioengineering and nanomedicine. This review focuses on three topics that highlight the latest findings on MPC polymers, that is, specific recognition of C-reactive protein (CRP), cell-membrane-penetration abilities, and lubrication properties. These developments will extend the applications of this biomimetic material from bioinert polymers to biosensing, CRP inhibitors, prodrug carriers, subcellular bioimaging, cell manipulation, and joint replacement. (C) 2015 Wiley Periodicals, Inc.
机译:2-甲基丙烯酰氧基乙基磷酰胆碱(MPC)是一种定制的甲基丙烯酸酯,在侧链上具有两性离子磷酰胆碱部分。在过去的25年中,由于MPC对非特异性蛋白质吸附,细胞粘附和血液凝固具有出色的抵抗力,因此已被用作各种聚合物生物材料的基础。最近,具有特定功能的MPC聚合物已用于生物工程和纳米医学中。这篇综述集中在三个主题上,这些主题突出显示了MPC聚合物的最新发现,即对C反应蛋白(CRP)的特异性识别,细胞膜渗透能力和润滑性能。这些进展将把这种仿生材料的应用范围从生物惰性聚合物扩展到生物传感,CRP抑制剂,前药载体,亚细胞生物成像,细胞操纵和关节置换。 (C)2015威利期刊公司

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