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首页> 外文期刊>Journal of Applied Polymer Science >Controlled-release drug carriers based hierarchical silica microtubes templated from cellulose acetate nanofibers
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Controlled-release drug carriers based hierarchical silica microtubes templated from cellulose acetate nanofibers

机译：以醋酸纤维素纳米纤维为模板的基于控释药物载体的分级硅胶微管

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摘要

We report a facile method to synthesize hollow silica microtubes (SMTs) from electrospun cellulose acetate fiber precursors. Specific surface areas of up to 765 m(2)/g (Brunauer-Emmett-Teller) were measured for the SMTs, which had a typical wall thickness of approximate to 100 nm and submicron inner diameters. An average pore size of 4.6 nm and pore volume of 0.41 cm(3)/g were derived from Barrett-Joyner-Halenda fitting, whereas Horvath-Kawazoe pore size distribution analysis revealed microporous median pore size and maximum pore volume of 0.7 nm and 0.18 cm(3)/g, respectively. The as-prepared SMTs featuring micro- and mesoporous structures in the walls where amino-functionalized to facilitate a very high drug loading (15% by weight). Drug release profile revealed sustained release rates (79% of acetylsalicylic acid was released after 6 h). It is concluded that the high drug loading and sustained release resulted from the advantageous integration of SMTs' hollow structure and wall mesoporosity. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42562.
机译：我们报告了一种从静电纺丝醋酸纤维素纤维前体合成空心二氧化硅微管（SMT）的简便方法。对于SMT，测量的比表面积高达765 m（2）/ g（Brunauer-Emmett-Teller），其典型壁厚约为100 nm，并且具有亚微米内径。 Barrett-Joyner-Halenda拟合得出的平均孔径为4.6 nm，孔体积为0.41 cm（3）/ g，而Horvath-Kawazoe孔径分布分析显示微孔中值孔径和最大孔径为0.7 nm和0.18 cm（3）/ g。所制备的SMT在壁上具有微孔和中孔结构，其中氨基官能化以促进非常高的载药量（按重量计15％）。药物释放曲线显示了持续释放速率（6小时后释放了79％的乙酰水杨酸）。结论是高载药量和缓释是由于SMT的空心结构和壁介孔性的有利整合。 （c）2015 Wiley Periodicals，Inc. J. Appl。 Polym。科学2015，132，42562。

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