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Formula and process optimization of controlled-release microcapsules prepared using a coordination assembly and the response surface methodology

机译:使用配位组件和响应面方法制备的控释微胶囊的配方和工艺优化

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A model chlorpyrifos microcapsule was prepared using coordination assembly between Fe3+ and tannic acid (TA). The influence of independent variables such as the dropping rate of TA (X-1) and Fe3+ (X-3), the concentration of TA (X-2) and Fe3+ (X-4), and the reaction temperature (X-5) on the encapsulation efficiency (R-1) and release characteristics (R-2) of the microcapsule had been investigated, based on a central composite design with five factors and five levels. The results showed that the main factors influencing R-1 and R-2 were X-4 and X-2, then the interaction between X-2 and X-4, followed by X-5 and X-3. The optimal formula mainly based on higher R-1 and lower R-2 were determined and then tested. The optimized conditions led to an encapsulation efficiency and cumulative release proportion of 97.12%+/- 0.72% and 40.07%+/- 0.53%, along with the average relative errors of predicted values being 1.78% and -1.60%, respectively. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 132, 42865.
机译:使用Fe3 +和单宁酸(TA)之间的配位组装制备了毒死rif微胶囊模型。 TA(X-1)和Fe3 +(X-3)的滴加速率,TA(X-2)和Fe3 +(X-4)的浓度以及反应温度(X-5)等自变量的影响),基于具有五个因素和五个层次的中心复合设计,研究了微囊的包封效率(R-1)和释放特性(R-2)。结果表明,影响R-1和R-2的主要因素是X-4和X-2,然后是X-2和X-4之间的相互作用,其次是X-5和X-3。确定并测试了主要基于较高R-1和较低R-2的最佳公式。优化条件导致包封效率和累积释放比例分别为97.12%+ /-0.72%和40.07%+ /-0.53%,预测值的平均相对误差分别为1.78%和-1.60%。 (c)2015 Wiley Periodicals,Inc. J. Appl。 Polym。科学2016,132,42865。

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