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首页> 外文期刊>Journal of Applied Polymer Science >Improvement of the mechanical properties of chitosan-alginate wound dressings containing silver through the addition of a biocompatible silicone rubber
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Improvement of the mechanical properties of chitosan-alginate wound dressings containing silver through the addition of a biocompatible silicone rubber

机译：通过添加生物相容性硅橡胶改善含银的壳聚糖-海藻酸盐伤口敷料的机械性能

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The benefits of associating chitosan with alginate for the production of wound dressings are well documented. However, the mechanical resistance of these devices is limited. This work aimed to improve the mechanical properties of chitosan-alginate membranes both with and without the microbicide agent AlphaSan((R)) RC2000 (silver sodium hydrogen zirconium phosphate) by incorporating the liquid silicone rubber Silpuran((R)) 2130 A/B. Membranes containing AlphaSan((R)) RC2000 but without Silpuran((R)) 2130 A/B have increased opacity, thickness, and water absorption, but low stability in water and tensile strength. The silicone gel remained in the structure of the formulations even after successive washing steps and its inclusion in the membranes reduced their thickness and swelling in aqueous media, improving their homogeneity, adhesiveness, stability, tensile strength, and flexibility. Thus, the addition of Silpuran((R)) 2130 A/B proved to contribute positively to many relevant, particularly mechanical, properties of chitosan-alginate wound dressings whether or not they contained AlphaSan((R)) RC2000. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41686.
机译：壳聚糖与藻酸盐缔合用于生产伤口敷料的好处已得到充分证明。但是，这些设备的机械阻力是有限的。这项工作旨在通过掺入液体硅橡胶Silpuran（R）2130 A / B来改善含有和不含杀微生物剂AlphaSan（R）RC2000（磷酸氢银锆）的壳聚糖-海藻酸盐膜的机械性能。 。含有AlphaSan（R）RC2000但不具有Silpuran（R）2130 A / B的膜具有增加的不透明性，厚度和吸水率，但是在水中的稳定性和拉伸强度低。即使在连续的洗涤步骤之后，硅凝胶仍保留在制剂的结构中，并且其在膜中的存在减小了其厚度和在水性介质中的溶胀，从而改善了其均一性，粘合性，稳定性，拉伸强度和柔韧性。因此，证明添加Silpuran2130A/ B对壳聚糖-海藻酸盐伤口敷料的许多相关的，特别是机械性能具有积极的贡献，无论它们是否包含AlphaSanRC2000。 （c）2014 Wiley Periodicals，Inc. J. Appl。 Polym。科学2015，132，41686。

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