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首页> 外文期刊>Journal of Applied Polymer Science >Disposable potentiometric citrate sensor based on polypyrrole-doped films for indirect determination of sildenafil in pharmaceuticals formulations
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Disposable potentiometric citrate sensor based on polypyrrole-doped films for indirect determination of sildenafil in pharmaceuticals formulations

机译：基于聚吡咯掺杂膜的一次性柠檬酸电位传感器，用于间接测定药物制剂中西地那非

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摘要

A new sensitive and selective disposable potentiometric sensor based on polypyrrole (PPy) films for determination of sildenafil citrate (SC) was proposed. The pyrrole polymerization was performed in presence of citrate ions under galvanostatic conditions which resulted in a membrane of PPy doped with citrate anion at graphite pencil electrode surface. Experimental conditions (e.g., pH and conditioning time) and instrumental parameters (e.g., current density and electrical charge) were evaluated in order to reach the best potentiometric response for the proposed sensor. Under optimized conditions, the device presented a linear dynamic range (LDR) for citrate ions concentrations varying from 0.034 to 1.7 mmol L-1 with a Nernstian slope of 57.2 mV dec(-1) and a limit of detection (LOD) of 30 mmol L-1. The developed potentiometric sensor was applied for sildenafil citrate (SC) determination (pharmaceutical formulations) and results compared with an official spectrophotometric method indicating a good agreement for a confidence level of 95%. Effect of concomitants species on the potentiometric response of the proposed device and morphologic characterization using microscopy of atomic force (AFM) were realized. The surface roughness of PPy films (synthesized in citrate solution and chloride) showed poorly affected by changing the doping anion, probably because the polypyrrole nodules grow three-dimensionally simultaneously. (C) 2016 Wiley Periodicals, Inc.
机译：提出了一种新型的基于聚吡咯（PPy）薄膜的灵敏，选择性的一次性电位计，用于测定枸den酸西地那非（SC）的含量。吡咯聚合在恒电流条件下在柠檬酸根离子的存在下进行，这导致在石墨笔电极表面掺杂了柠檬酸根阴离子的PPy膜。对实验条件（例如pH和调节时间）和仪器参数（例如电流密度和电荷）进行了评估，以实现所建议传感器的最佳电位响应。在优化条件下，该设备对柠檬酸离子浓度范围从0.034至1.7 mmol L-1的线性动态范围（LDR）具有57.2 mV dec（-1）的Nernstian斜率和30 mmol的检测极限（LOD） L-1。研制的电位传感器用于柠檬酸西地那非（SC）的测定（药物制剂），结果与官方的分光光度法比较，表明可信度达95％。实现了伴随物种对所提出的装置的电位响应和使用原子力显微镜（AFM）进行形态表征的影响。 PPy膜（在柠檬酸盐溶液和氯离子中合成）的表面粗糙度受掺杂阴离子的影响很小，这可能是因为聚吡咯根瘤同时在三维上生长。 （C）2016威利期刊公司

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