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首页> 外文期刊>Journal of Applied Polymer Science >Sustained release of potassium diclofenac from a pH-responsive hydrogel based on gum arabic conjugates into simulated intestinal fluid
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Sustained release of potassium diclofenac from a pH-responsive hydrogel based on gum arabic conjugates into simulated intestinal fluid

机译：从基于阿拉伯胶结合物的pH响应水凝胶中将双氯芬酸钾持续释放到模拟肠液中

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摘要

This work describes the preparation, the swelling properties and the potassium diclofenac (KDF) release profile of hydrogels of gum arabic (GA), N,N-dimethylacrylamide, and methacrylic acid. In order to convert GA into a hydrogel, the polysaccharide was vinyl-modified with glycidyl methacrylate. The hydrogels showed pH-responsive swelling changes, which were more expressive in the basic environment. Release data of KDF were adjusted to a diffusion-based kinetic model that provides an important insight on affinity of the drug for hydrogel and solvent, which may be the leading parameter for release of guest molecules from polymers. The KDF release from the hydrogels into simulated intestinal fluid decreases when the amount of modified GA increases. This was demonstrated to be due to the higher affinity of KDF for GA-richer hydrogel, which makes the anti-inflammatory release less favorable. The analysis of released drug half-time (t(1/2)=16.10 and 21.51 h) indicated sustained release characteristics. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43319.
机译：这项工作描述了阿拉伯树胶（GA），N，N-二甲基丙烯酰胺和甲基丙烯酸水凝胶的制备，溶胀特性和双氯芬酸钾（KDF）释放曲线。为了将GA转化为水凝胶，用甲基丙烯酸缩水甘油酯对多糖进行乙烯基改性。水凝胶显示出pH响应的溶胀变化，在碱性环境中更具表达力。将KDF的释放数据调整为基于扩散的动力学模型，该模型提供了关于药物对水凝胶和溶剂的亲和力的重要见解，这可能是客体分子从聚合物释放的主要参数。当修饰的GA的量增加时，从水凝胶释放到模拟肠液中的KDF减少。事实证明，这是由于KDF对富含GA的水凝胶的亲和力更高，这使得抗炎剂的释放不太理想。释放药物半衰期（t（1/2）= 16.10和21.51 h）的分析表明了缓释特性。 （c）2015 Wiley Periodicals，Inc. J. Appl。 Polym。科学2016，133，43319。

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