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首页> 外文期刊>Journal of Applied Polymer Science >beta-cyclodextrin-conjugated hyaluronan hydrogel as a potential drug sustained delivery carrier for wound healing
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beta-cyclodextrin-conjugated hyaluronan hydrogel as a potential drug sustained delivery carrier for wound healing

机译：β-环糊精偶联的透明质酸水凝胶作为伤口愈合的潜在药物缓释载体

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摘要

In order to develop a potential drug sustained delivery carrier suitable for wound healing, a series of beta-cyclodextrin conjugated hyaluronan hydrogels (beta-CD-HA) with adjustable crosslink densities were synthesized and characterized, meanwhile the delivery kinetics and mechanism of diclofenac as a model anti-inflammatory drug from these hydrogels were investigated. By controlling the feeding molar ratio of beta-CD/HA, a beta-CD substitution degree of 4.65% was obtained by H-1-NMR analysis. The incorporation of beta-CD modification had little effect on the internal porous structure, water swelling ratio, and rheological property of HA hydrogel, which however were influenced by the crosslink density. Although the crosslink density had an influence on the drug loading and release profile by altering the water swelling property, the interaction between beta-CD and drug was the primary factor for the high loading capacity and long-term sustained delivery of diclofenac. The semiempirical equation fit showed that the release of diclofenac from HA-based hydrogels followed a pseudo-Fickian diffusion mechanism. By the aid of beta-CD and controlled crosslink density, a beta-CD-HA hydrogel with a diclofenac sustained delivery period of over 28 days and desirable physicochemical properties was achieved, which will be a promising drug sustained delivery carrier for wound healing. (C) 2015 Wiley Periodicals, Inc.
机译：为了开发潜在的适合伤口愈合的药物持续传递载体，合成并表征了一系列具有可调节交联密度的β-环糊精偶联的透明质酸水凝胶（β-CD-HA），同时双氯芬酸作为一种药物的传递动力学和机理。研究了来自这些水凝胶的模型抗炎药。通过控制β-CD/ HA的进料摩尔比，通过H-1-NMR分析获得β-CD取代度为4.65％。 β-CD改性剂的掺入对HA水凝胶的内部多孔结构，水溶胀率和流变性没有什么影响，但是受交联密度的影响。尽管交联密度通过改变水溶胀性而影响药物的负载和释放特性，但β-CD和药物之间的相互作用是双氯芬酸高负载量和长期持续递送的主要因素。半经验方程拟合表明，双氯芬酸从HA基水凝胶中的释放遵循拟菲克扩散机制。借助于β-CD和受控的交联密度，获得了具有双氯芬酸持续递送期超过28天并且具有所需理化性质的β-CD-HA水凝胶，这将是用于伤口愈合的有希望的药物持续递送载体。 （C）2015年Wiley Periodicals，Inc.

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