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Zwitterionic-polymer-functionalized poly(vinyl alcohol-co-ethylene) nanofiber membrane for resistance to the adsorption of bacteria and protein

机译:两性离子聚合物功能化的聚乙烯醇-乙烯共聚物纳米纤维膜,可抵抗细菌和蛋白质的吸附

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A zwitterionic poly(vinyl alcohol-co-ethylene) (PVA-co-PE) nanofiber membrane for resistance to bacteria and protein adsorption was fabricated by the atom transfer radical polymerization of sulfobetaine methacrylate (SBMA). The PVA-co-PE nanofiber membrane was first surface-activated by a-bromoisobutyryl bromide, and then, zwitterionic SBMA was initiated to polymerize onto the surface of nanofiber membrane. The chemical structures of the functionalized PVA-co-PE nanofiber membranes were confirmed by attenuated total reflectance-Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The morphologies of the PVA-co-PE nanofiber membranes were characterized by scanning electron microscopy. The results show that the poly(sulfobetaine methacrylate) (PSBMA) was successfully grafted onto the PVA-co-PE nanofiber membrane, and the surface of the nanofiber membrane was more hydrophilic than that of the pristine membrane. Furthermore, the antibacterial adsorption properties and resistance to protein adsorption of the surface were investigated. This indicated that the PSBMA-functionalized surface possessed good antibacterial adsorption activity and resistance to nonspecific protein adsorption. Therefore, this study afforded a convenient and promising method for preparing a new kind of soft and nonwoven dressing material with antibacterial adsorption and antifouling properties that has potential use in the medical field. (C) 2016 Wiley Periodicals, Inc.
机译:通过磺基甜菜碱甲基丙烯酸酯(SBMA)的原子转移自由基聚合,制备了一种具有抗细菌和蛋白质吸附性能的两性离子聚乙烯醇-聚乙烯(PVA-co-PE)纳米纤维膜。首先用α-溴异丁酰基溴对PVA-co-PE纳米纤维膜进行表面活化,然后引发两性离子SBMA聚合到纳米纤维膜的表面。通过衰减全反射-傅立叶变换红外光谱和X射线光电子能谱确认了功能化PVA-co-PE纳米纤维膜的化学结构。通过扫描电子显微镜表征了PVA-co-PE纳米纤维膜的形态。结果表明,聚(磺基甜菜碱甲基丙烯酸甲酯)(PSBMA)已成功接枝到PVA-co-PE纳米纤维膜上,并且该纳米纤维膜的表面比原始膜的亲水性更高。此外,研究了表面的抗菌吸附性能和对蛋白质吸附的抗性。这表明PSBMA-官能化的表面具有良好的抗菌吸附活性和对非特异性蛋白质吸附的抵抗力。因此,本研究提供了一种方便且有前途的方法,用于制备具有抗菌吸附和防污性能的新型柔软无纺敷料,在医学领域具有潜在用途。 (C)2016威利期刊公司

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