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首页> 外文期刊>Journal of Applied Polymer Science >In vitro nifedipine release from poly(lactic acid)/chitosan nanoparticles loaded with nifedipine
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In vitro nifedipine release from poly(lactic acid)/chitosan nanoparticles loaded with nifedipine

机译：载有硝苯地平的聚乳酸/壳聚糖纳米颗粒的体外硝苯地平释放

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摘要

In this study, nanoparticles based on poly(lactic acid) (PLA), chitosan (CS), and nifedipine (NIF) were prepared by an emulsion method with poly(ethylene oxide) (PEO) as an emulsifier. We investigated the most suitable conditions for preparing the poly(lactic acid)/chitosanifedipine nanoparticles (PCNs) by changing the distilled water volume, PEO content, and PLA/CS ratio. NIFs with different contents were loaded into poly(lactic acid)/chitosan nanoparticles (PCs) to study in vitro drug-delivery systems. The PCNs were characterized with a Zetasizer particle size analyzer, field emission scanning electron microscopy, Fourier transform infrared (FTIR) spectroscopy, and X-ray diffraction (XRD) methods. From the obtained results of the particle size parameters of the PCNs, the most suitable conditions for the preparation of the PCNs were found. The FTIR spectroscopy and XRD results show that NIF was loaded into the PCs. The PCNs had major basic particle sizes in the range 20-40nm. NIF release from the PCNs was studied as a function of the pH of the immersed solution, the immersion time, and the NIF content. The kinetics of drug release were investigated and are reported to determine the type of release mechanism. (c) 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43330.
机译：在这项研究中，通过以聚环氧乙烷（PEO）为乳化剂的乳液法制备了基于聚乳酸（PLA），壳聚糖（CS）和硝苯地平（NIF）的纳米颗粒。我们研究了通过更改蒸馏水量，PEO含量和PLA / CS比来制备聚乳酸/壳聚糖/硝苯地平纳米颗粒（PCNs）的最合适条件。将具有不同含量的NIF加载到聚乳酸/壳聚糖纳米颗粒（PC）中，以研究体外药物递送系统。使用Zetasizer粒度分析仪，场发射扫描电子显微镜，傅里叶变换红外（FTIR）光谱和X射线衍射（XRD）方法对PCN进行表征。从PCN的粒度参数的获得结果，发现了制备PCN的最合适条件。 FTIR光谱和XRD结果表明NIF已加载到PC中。 PCN具有20-40nm的主要基本粒径。研究了PCN中NIF释放与浸入溶液的pH，浸入时间和NIF含量的关系。研究了药物释放的动力学，并据报道确定了药物释放机理的类型。 （c）2016 Wiley Periodicals，Inc. J. Appl。 Polym。科学2016，133，43330。

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