• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Applied Polymer Science >Evaluation of alginate dialdehyde as a suitable crosslinker on modifying porcine acellular dermal matrix: The aggregation of collagenous fibers
【24h】

Evaluation of alginate dialdehyde as a suitable crosslinker on modifying porcine acellular dermal matrix: The aggregation of collagenous fibers

机译：评估藻酸盐二醛作为合适的交联剂对猪脱细胞真皮基质的改性作用：胶原纤维的聚集

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Porcine acellular dermal matrix (PADM) has been investigated widely as a natural biomaterial. However, the success of PADM has been limited by insufficient stability and poor physicochemical properties. In our work, alginate dialdehyde (ADA) with various oxidation degrees (OD=25%, 45%, and 65%) were explored to modify PADM, while glutaraldehyde (GA), dehydrathermal treatment (DHT), and carbodiimide (EDC) were used as the control. The efficacy of ADA on modifying PADM increased along with the rising of oxidation degree. The ADA (OD=65% and 45%) groups showed better mechanical and thermal stability, crosslink density, and resistance to enzymatic degradation than ADA (OD=25%) and DHT+EDC group. Meanwhile, the structure of PADM crosslinked by ADA (OD=45% and 65%) were maintained largely. Further, ADA (OD=45%) group revealed better cytocompatibility than DHT+EDC, ADA (OD=65%) and GA group. Considering the balance of cytocompatibility and physicochemical behavior, ADA (OD=45%) was more suitable as a natural derived crosslinker to modify PADM in tissue engineering. (c) 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43550.
机译：猪脱细胞真皮基质（PADM）已被广泛研究为天然生物材料。但是，PADM的成功受到稳定性不足和理化性质差的限制。在我们的工作中，探索了各种氧化度（OD = 25％，45％和65％）的藻酸盐二醛（ADA）来修饰PADM，而戊二醛（GA），脱水热处理（DHT）和碳二亚胺（EDC）则被修饰。用作控件。随着氧化度的提高，ADA对PADM的改性作用增强。与ADA（OD = 25％）和DHT + EDC组相比，ADA（OD = 65％和45％）组显示出更好的机械和热稳定性，交联密度以及对酶降解的抵抗力。同时，很大程度上保持了由ADA交联的PADM的结构（OD ＝ 45％和65％）。此外，ADA（OD = 45％）组显示出比DHT + EDC，ADA（OD = 65％）和GA组更好的细胞相容性。考虑到细胞相容性和理化行为的平衡，ADA（OD = 45％）更适合作为天然衍生的交联剂来修饰组织工程学中的PADM。 （c）2016 Wiley Periodicals，Inc. J. Appl。 Polym。科学2016，133，43550。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号