...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Branched chain amino acid metabolic reprogramming in heart failure
【24h】

Branched chain amino acid metabolic reprogramming in heart failure

机译：心力衰竭中的支链氨基酸代谢重编程

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Metabolic remodeling is a hall-mark of cardiac maturation and pathology. The switch of substrate utilization from glucose to fatty acid is observed during post-natal maturation period in developing heart, but the process is reversed from fatty acids to glucose in the failing hearts across different clinic and experimental models. Majority of the current investigations have been focusing on the regulatory mechanism and functional impact of this metabolic reprogramming involving fatty acids and carbohydrates. Recent progress in metabolomics and transcriptomic analysis, however, revealed another significant remodeled metabolic branch associated with cardiac development and disease, i.e. Branched-Chain Amino Acid (BCAA) catabolism. These findings have established BCAA catabolic deficiency as a novel metabolic feature in failing hearts with potentially significant impact on the progression of pathological remodeling and dysfunction. In this review, we will evaluate the current evidence and potential implication of these discoveries in the context of heart diseases and novel therapies. This article is part of a Special Issue entitled: The role of post-translational protein modifications on heart and vascular metabolism edited by Jason R.B. Dyck & Jan F.C. Glatz. (C) 2016 Elsevier B.V. All rights reserved.
机译：代谢重塑是心脏成熟和病理的标志。在发育中的心脏的产后成熟期间，可以观察到底物利用率从葡萄糖转换为脂肪酸，但是在不同的临床和实验模型中，该过程在衰竭心脏中从脂肪酸转换为葡萄糖。当前的研究多数集中在这种涉及脂肪酸和碳水化合物的代谢重编程的调节机制和功能影响上。然而，代谢组学和转录组学分析的最新进展揭示了与心脏发育和疾病相关的另一个重要的重构代谢分支，即支链氨基酸（BCAA）分解代谢。这些发现已将BCAA分解代谢缺陷确定为心脏衰竭的一种新陈代谢特征，对病理重塑和功能障碍的发展可能具有重大影响。在这篇综述中，我们将评估心脏病和新型疗法背景下这些发现的当前证据和潜在意义。本文是特刊（Jason R.B. Dyck＆Jan F.C.）编辑的特刊的一部分：翻译后蛋白质修饰对心脏和血管代谢的作用。格拉茨（C）2016 Elsevier B.V.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号